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Table 4 Comparison of genotype, haplotype carrier rate, haplotype carrier frequencies and allele frequencies for IL-10 in IPF patients and healthy controls

From: Cytokine gene polymorphisms and serum cytokine levels in patients with idiopathic pulmonary fibrosis

IL-10 (−1082, -819, -592)

IPF (n = 60)

Healthy controls (n = 150)

*p-value

OR

95% CI

Genotype

     

 GCC GCCa

10 (16.7)

28 (18.7)

0.844

1.148

0.519 – 2.537

 GCC ACCb

13 (21.7)

31 (20.7)

0.853

0.942

0.454 – 1.955

 GCC ATAc

14 (23.3)

33 (22)

0.856

0.927

0.455 – 1.889

 ACC ACCd

7 (11.7)

16 (10.7)

0.811

0.904

0.352 – 2.322

 ACC ATAe

8 (13.3)

21 (14)

1.000

1.058

0.441 – 2.540

 ATA ATAf

8 (13.3)

21 (14)

1.000

1.058

0.441 – 2.540

Haplotype carrier rate

     

 GCC carriers

37 (61.7)

92 (61.3)

0.964

0.986

0.533 – 1.825

 ACC carriers

28 (46.7)

68 (45.3)

0.861

0.948

0.520 – 1.728

 ATA carriers

30 (50)

75 (50)

1.000

1.000

0.549 – 1.820

Haplotype frequency

    

 GCC

0.392

0.400

0.935

1.021

0.616 – 1.693

 ACC

0.292

0.280

0.737

0.916

0.549 – 1.528

 ATA

0.316

0.320

0.993

0.998

0.602 – 1.653

Allele

      

 −1082

G alleleg

47 (39.2)

120 (40)

0.912

0.966

0.626 – 1.489

 

A allele

73 (60.8)

180 (60)

   

 −819

C alleleh

82 (68.3)

204 (68)

1.000

1.015

0.644 – 1.600

 

T allele

38 (31.7)

96 (32)

   

 −592

C allelei

82 (68.3)

204 (68)

1.000

1.015

0.644 – 1.600

 

A allele

38 (31.7)

96 (32)

   
  1. Data are presented as number (with percentages).
  2. Abbreviations: IL interleukin, IPF idiopathic pulmonary fibrosis, OR odds ratio, CI confidence interval.
  3. *Chi-square or Fisher’s exact tests were used to compare frequencies between genotypes and alleles.
  4. aGCC GCC vs. other IL-10 genotypes.
  5. bGCC ACC vs. other IL-10 genotypes.
  6. cGCC ATA vs. other IL-10 genotypes.
  7. dACC ACC vs. other IL-10 genotypes.
  8. eACC ATA vs. other IL-10 genotypes.
  9. fATA ATA vs. other IL-10 genotypes.
  10. gG vs. A allele.
  11. hC vs. T allele.
  12. iC vs. A allele.