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Table 1 Different phenotypes and diseases associated with radiation SNPs, identified through VARIMED

From: Systematic identification of DNA variants associated with ultraviolet radiation using a novel Geographic-Wide Association Study (GeoWAS)

Disease/Trait

SNP ID (rs)

R-value (Pearson)

Function type

Gene

Ancestral allele

P-min

Obesity

10508503

0.841646

Intergenic

-

C

1.10 Ă— 10-7

Eye color

10809808

0.800649

Intergenic

-

T

5.80 Ă— 10-12

Asthma

10922300

0.805829

Intergenic

-

C

7.44 Ă— 10-11

Coffee consumption

11856835

0.811979

Intron

SEMA7A

G

1.10 Ă— 10-7

HDL cholesterol levels

1263173

0.815426

Intergenic

-

G

2.13 Ă— 10-7

Transferrin receptor levels

1263173

0.815426

Intergenic

-

G

6.80 Ă— 10-14

Eye color

12913832

0.801066

Intron

HERC2

A

1.00 Ă— 10-11

Hair color

12913832

0.801066

Intron

HERC2

A

8.51 Ă— 10-10

Basal cell carcinoma*

16891982

-0.83108

Missense

SLC45A2

G

1.60 Ă— 10-12

Eye color

16891982

-0.83108

Missense

SLC45A2

G

1.48 Ă— 10-12

Hair color

16891982

-0.83108

Missense

SLC45A2

G

3.89 Ă— 10-11

Malignant melanoma*

16891982

-0.83108

Missense

SLC45A2

G

2.00 Ă— 10-8

Melanoma*

16891982

-0.83108

Missense

SLC45A2

G

8.30 Ă— 10-15

Skin color

16891982

-0.83108

Missense

SLC45A2

G

1.70 Ă— 10-9

Skin pigmentation

16891982

-0.83108

Missense

SLC45A2

G

5.02 Ă— 10-8

Squamous cell carcinoma*

16891982

-0.83108

Missense

SLC45A2

G

1.00 Ă— 10-7

Hair color

28777

0.805006

Intron

SLC45A2

C

1.10 Ă— 10-8

Freckles

2153271

0.800255

Intron

BNC2

C

3.98 Ă— 10-10

Metabolite traits

2286963

0.813366

Missense

ACADL

T

3.10 Ă— 10-12

Coffee consumption

2470893

-0.80281

Near Gene5

CYP1A1

T

2.90 Ă— 10-9

Amyloid beta-protein levels

2899472

0.81232

Intron

CYP19A1

C

1.90 Ă— 10-12

Hair color

3829241

0.831729

Missense

TPCN2

G

6.20 Ă— 10-14

HDL cholesterol levels

496300

0.813658

Intergenic

-

T

3.90 Ă— 10-7

Hair color

7196459

0.841939

Intron

PRDM7

G

3.10 Ă— 10-15

Colorectal cancer*

7259371

0.812093

Intron

RHPN2

A

2.20 Ă— 10-7

Height

798489

0.808614

Intron

GNA12

C

1.90 Ă— 10-8

Bone mineral density

884205

0.806085

Intergenic

-

C

9.40 Ă— 10-9

  1. Empty values in the gene column indicate that the corresponding SNP is located outside of a gene region. Cancerous phenotypes are highlighted with an asterisk. As many of the same SNPs have been repeatedly identified for varying but similar diseases and conditions, these are not independent traits.