Figure 2

Dendrogram and graph of entropy with the genes interaction and their polymorphisms in response to Bhalla score. A. Dendrogram with the genes interaction and their polymorphisms in response to Bhalla score (BS). The stronger interaction of response to Bhalla clinical score is given by CFTR mutations and GSTM1 and GSTT1 genes deletion. Secondly, the polymorphism GSTP1*+313A> G was associated with the clinical variable. Polymorphisms GCLC*-129C>T and GCLC*-350A>G were not associated with the BS. B. Graph of entropy measuring the power of different genotypes and the interaction between them, for the genes analyzed in the gene-gene interaction with BS. The CFTR mutation gene, GSTP1*+313A>G and GSTM1 and GSTT1 deletion polymorphisms showed significant association with BS. The CFTR mutation showed influence of 3.38% for BS, the GSTM1 and GSTT1 deletion together, showed 2.82% of influence, while the GSTP1*+313A>G showed influence of 0.5%. The CFTR mutation showed a value of 4.15% for the interaction between the deletion polymorphism with GSTM1 and GSTT1 genes and 3.57% for the association with GSTP1*+313A>G. The dendrogram construction was performed by the software MDR2.0. The analysis included 180 Cystic Fibrosis patients. # Association of GCLC-129C>T, GCLC-350A>G, GSTP1+313A>G, GSTM1 and GSTT1 genes deletion and CFTR mutations with the BS show a p-value of 0.0080. CFTR - Cystic Fibrosis Transmembrane Regulator; GCLC - glutamate-cysteine ligase, catalytic subunit; GSTP1 - glutathione S-transferase P1; GSTM1 - glutathione S-transferase M1; GSTT1 - glutathione S-transferase T1. The power of interaction is show by the distance between the two genes on the figure A in horizontal direction. The redundancy/synergy power is show in the figure B by the color intensity.