Table 3 Case–control frequencies of the alleles and genotypes of the polymorphisms on FGF12 , VCL , CX43 and VAX1
HWE* (p value) | Control Group (%) | CL ± P Group (%) | ORallele(95% CI) p value | CLO Group (%) | ORallele(95% CI) p value | CLP Group (%) | ORallele(95% CI) p value | |
|---|---|---|---|---|---|---|---|---|
FGF12 | ||||||||
rs6790664 | ||||||||
Allele (A/C) | 0.79 | 50.5/49.5 | 50.5/49.5 | 1.00 (0.80-1.24) | 55.3/44.7 | 0.83 (0.61-1.12) | 48/52 | 1.11 (0.87-1.41) |
Genotype (AA/AC/CC) | 25.2/50.6/24.2 | 24.7/51.7/23.6 | 0.50 | 28.6/53.4/18 | 0.28 | 22.6/50.7/26.7 | 0.56 | |
rs11717284 | ||||||||
Allele (A/T) | 0.42 | 51.5/48.5 | 55.5/44.5 | 0.85 (0.68-1.06) | 49/51 | 1.10 (0.81-1.50) | 59/41 | 0.74 (0.58-0.95) |
Genotype (AA/AT/TT) | 27.6/47.9/24.5 | 30.5/50.1/19.4 | 0.36 | 22.1/53.9/24 | 0.22 | 34.9/48.2/16.9 | 0.91 | |
rs1464942 | ||||||||
Allele (A/T) | 0.06 | 27.8/72.2 | 29.6/70.4 | 0.91 (0.72-1.16) | 31/69 | 0.85 (0.61-1.19) | 28.9/71.1 | 0.94 (0.72-1.24) |
Genotype (AA/AT/TT) | 9.6/36.4/54 | 8.7/41.8/49.5 | 0.74 | 8.6/44.8/46.6 | 0.59 | 8.8/40.2/51 | 0.50 | |
rs12106855 | ||||||||
Allele (A/G) | 0.15 | 42.1/57.9 | 40.8/59.2 | 1.05 (0.85-1.31) | 43.3/56.7 | 0.95 (0.69-1.29) | 39.3/60.7 | 1.12 (0.87-1.43) |
Genotype (AA/AG/GG) | 19.5/45.2/35.3 | 17.2/47/35.8 | 0.23 | 17.1/52.4/30.5 | 0.22 | 17.3/44.1/38.6 | 0.53 | |
rs1875735 | ||||||||
Allele (C/G) | 0.14 | 46.1/53.9 | 46.8/53.2 | 0.97 (0.78-1.20) | 44.8/55.2 | 1.06 (0.77-1.43) | 48/52 | 0.93 (0.72-1.18) |
Genotype (CC/CG/GG) | 23.1/46/30.9 | 23.4/47/29.6 | 0.44 | 21/47.6/31.4 | 0.28 | 24.6/46.7/28.7 | 0.76 | |
VCL | ||||||||
rs4746172 | ||||||||
Allele (C/T) | 0.89 | 27.2/72.8 | 27.2/72.8 | 1.00 (0.78-1.27) | 24.3/75.7 | 1.16 (0.82-1.66) | 28.7/71.3 | 0.93 (0.71-1.22) |
Genotype (CC/CT/TT) | 7.5/39.3/53.2 | 7/40.4/52.6 | 0.83 | 2.9/42.8/54.3 | 0.92 | 9.2/39/51.8 | 0.59 | |
rs10762573 | ||||||||
Allele (A/C) | 0.46 | 33.9/66.1 | 32.8/67.2 | 1.05 (0.83-1.32) | 34.3/65.7 | 0.98 (0.71-1.35) | 32/68 | 1.09 (0.84-1.42) |
Genotype (AA/AC/CC) | 10.6/46.5/42.9 | 12.7/40.2/47.1 | 0.94 | 16.2/36.2/47.6 | 0.57 | 10.8/42.2/47 | 0.92 | |
rs2131960 | ||||||||
Allele (A/C) | 0.45 | 62.6/34.4 | 67.9/32.1 | 0.90 (0.72-1.13) | 68.8/31.2 | 0.87 (0.62-1.21) | 67.5/32.5 | 0.92 (0.71-1.19) |
Genotype (AA/AC/CC) | 42.1/46.9/11 | 47.5/40.8/11.7 | 0.62 | 50/37.5/12.5 | 0.23 | 46.1/42.6/11.3 | 0.95 | |
CX43 | ||||||||
rs11961755 | ||||||||
Allele (A/G) | 0.73 | 20.4/79.6 | 21.9/78.1 | 0.91 (0.70-1.19) | 21.4/78.6 | 0.94 (0.64-1.36) | 22/78 | 0.90 (0.67-1.22) |
Genotype (AA/AG/GG) | 4.4/31.9/63.7 | 4.4/35/60.6 | 0.68 | 2.9/37.1/60 | 0.90 | 5.2/33.8/61 | 0.74 | |
rs12197797 | ||||||||
Allele (C/G) | 0.70 | 79/21 | 79/21 | 0.99 (0.76-1.29) | 78.7/21.3 | 1.02 (0.70-1.49) | 79.3/20.7 | 0.98 (0.72-1.33) |
Genotype (CC/CG/GG) | 62.7/32.5/4.8 | 61.6/35/3.4 | 0.94 | 59.2/38.8/2 | 0.97 | 62.8/33/4.2 | 0.94 | |
VAX1 | ||||||||
rs7086344 | ||||||||
Allele (C/T) | 0.23 | 82/18 | 82.5/17.5 | 0.96 (0.73-1.27) | 82.4/17.6 | 0.97 (0.65-1.45) | 82.6/17.4 | 0.96 (0.69-1.32) |
Genotype (CC/CT/TT) | 68/27.8/4.2 | 69.7/25.7/4.6 | 0.12 | 66.7/31.4/1.9 | 0.63 | 71.3/22.6/6.1 | 0.16 | |
rs10787760 | ||||||||
Allele (A/G) | 0.11 | 63.6/36.4 | 62.7/37.3 | 1.04 (0.83-1.290 | 61.9/38.1 | 1.07 (0.78-1.47) | 63/37 | 1.02 (0.79-131) |
Genotype (AA/AG/G) | 42.3/42.6/15.1 | 39.7/46/14.3 | 0.42 | 40/43.8/16.2 | 0.85 | 39.5/47.1/13.4 | 0.46 | |
rs6585429 | ||||||||
Allele (A/G) | 0.09 | 26.3/73.7 | 30.4/69.6 | 0.82 (0.64-1.04) | 32/68 | 0.75 (0.54-1.06) | 29.5/70.5 | 0.85 (0.65-1.12) |
Genotype (AA/AG/GG) | 8.6/35.4/56 | 9.8/41.2/49 | 0.43 | 11.6/40.8/47.6 | 0.46 | 8.7/41.5/49.8 | 0.72 | |
rs1871345 | ||||||||
Allele (C/T) | 0.06 | 76/24 | 75.6/24.4 | 1.02 (0.79-1.31) | 74.3/25.7 | 1.09 (0.77-1.56) | 76.3/23.7 | 0.98 (0.74-1.31) |
Genotype (CC/CT/TT) | 59.5/32.9/7.6 | 56.6/38/5.4 | 0.96 | 55.4/37.8/6.8 | 0.56 | 57.2/38.1/4.7 | 0.85 | |
rs751231 | ||||||||
Allele (A/C) | 0.34 | 81.5/18.5 | 80.1/19.9 | 1.09 (0.83-1.43) | 78.9/21.1 | 1.18 (0.80-1.72) | 80.8/19.2 | 1.04 (0.76-1.42) |
Genotype (AA/AC/CC) | 67.1/28.8/4.1 | 63.3/33.7/3 | 0.83 | 61.5/34.6/3.9 | 0.16 | 64.3/33.1/2.6 | 0.91 | |
rs751233 | ||||||||
Allele (A/G) | 0.47 | 17/83 | 19.5/80.5 | 0.84 (0.64-1.11) | 20.7/79.3 | 0.78 (0.53-1.15) | 18.9/81.1 | 0.87 (0.64-1.20) |
Genotype (AA/AG/GG) | 3.4/27.1/69.5 | 3.7/31.6/64.7 | 0.58 | 3.8/33.7/62.5 | 0.24 | 3.6/30.6/65.8 | 0.83 |