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Table 3 Minor allele frequencies (MAF) and P-values for Hardy-Weinberg (HW) and association tests for SNPs with P<0.05 in the Chinese population

From: Investigating highly replicated asthma genes as candidate genes for allergic rhinitis

Gene

SNP ID

Chromosome position

Study MAF

HW test

Association test

OR

95% CI

Allele

Genotype

Lower

Upper

CTLA4

rs231735

2

204402121

0.23

1.0

0.00090

(0.037)

0.0038

(0.12)

1.44

1.16

1.79

CTLA4

rs231804

2

204416891

0.22

0.93

0.00060

(0.028)

0.0025

(0.090)

1.46

1.18

1.82

CTLA4

rs1024161

2

204429997

0.34

0.57

0.0088

(0.21)

0.020

(0.34)

1.29

1.07

1.56

CTLA4

rs926169

2

204430997

0.34

0.89

0.0059

(0.20)

0.016

(0.29)

1.31

1.08

1.58

CTLA4

rs733618

2

204439189

0.40

1.0

0.012

(0.22)

0.030

(0.42)

0.79

0.66

0.95

CTLA4

rs231726

2

204449111

0.40

0.74

0.016

(0.22)

0.041

(0.50)

1.25

1.04

1.51

CTLA4

rs6748358

2

204465150

0.28

0.39

0.0077

(0.21)

0.0067

(0.18)

1.31

1.08

1.61

CTLA4

rs10197319

2

204471289

0.22

0.86

0.013

(0.22)

0.0058

(0.17)

1.31

1.06

1.63

CTLA4

rs3096851

2

204472127

0.40

0.90

0.015

(0.22)

0.028

(0.41)

1.26

1.05

1.51

CTLA4

rs3116504

2

204477299

0.40

0.90

0.015

(0.22)

0.028

(0.41)

1.26

1.05

1.51

SPINK5

rs7707803

5

147368427

0.33

0.23

0.021

(0.27)

0.077

(0.57)

1.25

1.03

1.52

SPINK5

rs7725292

5

147368581

0.33

0.28

0.017

(0.22)

0.061

(0.51)

1.27

1.04

1.54

SPINK5

rs10477360

5

147384474

0.50

0.90

0.037

(0.34)

0.066

(0.52)

0.82

0.69

0.99

SPINK5

rs12332673

5

147387572

0.12

0.17

0.045

(0.36)

NA

(NA)

0.75

0.56

0.99

SPINK5

rs11948836

5

147393693

0.12

0.17

0.039

(0.34)

NA

(NA)

0.74

0.56

0.99

SPINK5

rs17774892

5

147395161

0.12

0.88

0.035

(0.34)

NA

(NA)

0.74

0.55

0.98

SPINK5

rs10463396

5

147395535

0.20

1.0

0.016

(0.22)

0.053

(0.50)

0.76

0.60

0.95

SPINK5

rs17107650

5

147396591

0.12

0.17

0.039

(0.34)

NA

(NA)

0.74

0.56

0.99

SPINK5

rs1422982

5

147400217

0.20

1.00

0.016

(0.22)

0.053

(0.50)

0.76

0.60

0.95

SPINK5

rs17107673

5

147401681

0.12

0.29

0.041

(0.34)

NA

(NA)

0.74

0.56

0.99

SPINK5

rs4472254

5

147433830

0.20

0.69

0.016

(0.22)

0.044

(0.50)

0.76

0.60

0.95

SPINK5

rs7724165

5

147445445

0.50

0.80

0.027

(0.30)

0.054

(0.50)

1.23

1.02

1.47

SPINK5

rs4519913

5

147452004

0.50

0.85

0.024

(0.27)

0.057

(0.50)

0.81

0.68

0.97

ADRB2

rs11742519

5

148218501

0.45

0.90

0.039

(0.34)

0.056

(0.50)

1.21

1.01

1.45

NPSR1

rs411323

7

34668233

0.16

0.81

0.037

(0.34)

0.095

(0.62)

1.31

1.02

1.69

NPSR1/AAA1

rs10081183

7

34706738

0.45

0.66

0.0066

(0.21)

0.023

(0.36)

0.78

0.65

0.93

NPSR1/AAA1

rs1345267

7

34714584

0.46

0.31

0.012

(0.22)

0.036

(0.48)

0.79

0.66

0.95

NPSR1/AAA1

rs1419791

7

34722086

0.48

0.85

0.0096

(0.21)

0.010

(0.21)

1.27

1.06

1.52

NPSR1/AAA1

rs1419791

7

34722086

0.48

0.85

0.0096

(0.21)

0.010

(0.21)

1.27

1.06

1.52

NPSR1/AAA1

rs324374

7

34723121

0.48

0.90

0.0095

(0.21)

0.010

(0.21)

1.27

1.06

1.52

NPSR1/AAA1

rs324389

7

34744239

0.46

0.66

0.00010

(0.014)

0.00055

(0.044)

0.70

0.58

0.84

NPSR1/AAA1

rs10270663

7

34752923

0.46

0.52

0.000068

(0.014)

0.00038

(0.044)

0.69

0.58

0.83

NPSR1/AAA1

rs324396

7

34756648

0.42

1.0

0.00035

(0.021)

0.0012

(0.065)

1.40

1.16

1.68

NPSR1/AAA1

rs324957

7

34767897

0.43

0.61

0.00011

(0.014)

0.00052

(0.044)

1.44

1.20

1.73

NPSR1/AAA1

rs10267134

7

34769628

0.34

0.89

0.00039

(0.021)

0.0014

(0.065)

0.71

0.58

0.86

NPSR1/AAA1

rs10278663

7

34774996

0.34

0.83

0.00032

(0.021)

0.0012

(0.065)

0.70

0.58

0.85

NPSR1

rs324987

7

34787953

0.44

0.34

0.00021

(0.019)

0.00049

(0.044)

1.41

1.18

1.70

NPSR1

rs17199888

7

34830864

0.33

0.89

0.0022

(0.083)

0.0075

(0.18)

0.74

0.61

0.90

NPSR1

rs1419868

7

34834082

0.25

0.018

0.013

(0.22)

0.054

(0.50)

1.31

1.06

1.61

GSTP1

rs614080

11

67103863

0.28

0.44

0.40

(0.80)

0.050

(0.50)

1.09

0.89

1.33

NOS1

rs884847

12

116207996

0.15

0.90

0.26

(0.75)

0.043

(0.50)

1.01

0.90

1.50

NOS1

rs532967

12

116216722

0.20

0.55

0.032

(0.34)

0.0024

(0.090)

1.03

1.02

1.62

NOS1

rs545654

12

116261432

0.32

0.47

0.019

(0.24)

0.043

(0.50)

1.19

0.65

0.96

NOS1

rs693534

12

116269101

0.28

0.64

0.0094

(0.21)

0.014

(0.29)

0.84

0.62

0.94

NOS1

rs3782221

12

116280264

0.49

0.31

0.024

(0.27)

0.047

(0.50)

1.08

0.67

0.97

NOS1

rs11068466

12

116320260

0.17

0.73

0.023

(0.27)

0.016

(0.29)

0.91

0.59

0.96

NOS1

rs10774914

12

116331323

0.12

0.56

0.042

(0.34)

0.10

(0.62)

1.13

1.01

1.78

IL4R

rs3024535

16

27259622

0.16

0.023

0.034

(0.34)

NA

(NA)

1.31

1.02

1.68

IL4R

rs3024585

16

27267345

0.38

0.12

0.034

(0.34)

0.088

(0.62)

0.82

0.68

0.99

IL4R

rs2074570

16

27282658

0.07

0.63

0.040

(0.34)

NA

(NA)

1.45

1.02

2.07

  1. †Association with AR estimated using a χ2-homogeneity test with Q-values in parenthesis calculated according to Storey (2002).
  2. Odds ratio (OR) and 95% confidence interval were estimated by using the most common allele as the referent and are reported for each minor allele.