Investigating highly replicated asthma genes as candidate genes for allergic rhinitis

BMC Medical Genetics

Table 1 Minor allele frequencies (MAF) and P-values for Hardy-Weinberg (HW) and association tests for SNPs with P<0.05 in the Swedish population

Gene	SNP ID	Chromosome position		Study MAF	HW test	Association test^†				OR	95% CI
Gene	SNP ID	Chromosome position		Study MAF	HW test	Allele		Genotype		OR	Lower	Upper
IL10	rs3021094	1	206944952	0.092	0.16	0.020	(0.72)	0.078	(0.92)	1.6	1.1	2.2
NOD1	rs4363092	7	30503938	0.18	0.36	0.050	(0.72)	0.045	(0.92)	1.3	1.0	1.8
NOD1	rs4720003	7	30508992	0.18	0.37	0.041	(0.72)	0.033	(0.92)	1.3	1.0	1.8
NPSR1	rs2022142	7	34705950	0.10	1.0	0.035	(0.72)	0.056	(0.92)	1.5	1.0	2.1
NPSR1	rs1379925	7	34715128	0.091	1.0	0.021	(0.72)	0.031	(0.92)	1.6	1.1	2.3
NPSR1	rs1379923	7	34717238	0.25	0.41	0.045	(0.72)	0.11	(0.92)	0.8	0.6	1.0
NPSR1	rs17788770	7	34793991	0.10	0.68	0.083	(0.72)	0.035	(0.92)	0.7	0.5	1.0
NPSR1	rs17789834	7	34871328	0.19	0.32	0.011	(0.70)	0.039	(0.92)	1.4	1.1	1.9
SCGB1A1	rs11231085	11	62190448	0.36	0.74	0.037	(0.72)	0.0049	(0.58)	1.3	1.0	1.6
CCL5	rs1065341	17	34198593	0.040	0.41	0.027	(0.72)	0.085	(0.92)	1.8	1.1	3.2
CCL5	rs3817655	17	34199641	0.17	0.12	0.0028	(0.29)	0.0088	(0.58)	1.6	1.2	2.1
CCL5	rs2107538	17	34207780	0.17	0.27	0.0021	(0.29)	0.0069	(0.58)	1.6	1.2	2.1
TBXA2R	rs3786989	19	3604004	0.93	0.25	0.038	(0.72)	0.086	(0.92)	0.6	0.4	1.0

†Association with AR estimated using a χ2-homogeneity test with Q-values in parenthesis calculated according to Storey (2002).
Odds ratio (OR) and 95% confidence interval were estimated by using the most common allele as the referent and are reported for each minor allele.

ISSN: 1471-2350