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Table 3 Summary of different comparative results

From: The associations between the polymorphisms in the CTLA-4gene and the risk of Graves’ disease in the Chinese population

Polymorphism

Genetic model

Participants

OR (95%CI)

Z

p-value

I2, %

P Het

Effect model

+49A/G

GG+GA vs. AA

7660

2.57(1.87,3.52)

5.83

< 0.00001

66.1

< 0.0001

Random

 

GG vs. GA+AA

7660

2.11(1.70,2.63)

6.69

< 0.00001

70.3

< 0.00001

Random

 

GG vs. AA

4402

3.87(2.59,5.80)

6.57

< 0.00001

74.3

< 0.00001

Random

 

GA vs. AA

4053

1.96(1.44,2.67)

4.25

< 0.00001

60.8

0.0006

Random

 

G vs. A

15320

1.88(1.58,2.23)

7.18

< 0.00001

76.8

< 0.00001

Random

−318C/T

TT+TC vs. CC

1701

0.78(0.62,0.97)

2.18

0.03

0

0.86

Fixed

 

TT vs. TC+CC

1701

0.76(0.37,1.53)

0.78

0.44

0

0.92

Fixed

 

TT vs. CC

1291

0.70(0.35,1.43)

0.97

0.33

0

0.90

Fixed

 

TC vs. CC

1672

0.78(0.62,0.98)

2.11

0.03

0

0.86

Fixed

 

T vs. C

3402

0.80(0.66,0.98)

2.12

0.03

0

0.88

Fixed

CT60 G/A

AA + AG vs. GG

1977

0.64(0.52,0.78)

4.34

< 0.0001

0

0.82

Fixed

 

AA vs. AG + GG

1977

0.43(0.26,0.72)

3.22

0.001

0

0.82

Fixed

 

AA vs. GG

1379

0.39(0.23,0.65)

3.62

0.0003

0

0.81

Fixed

 

AG vs. GG

1889

0.69(0.55,0.85)

3.52

0.0004

0

0.82

Fixed

 

A vs. G

3954

0.65(0.54,0.77)

4.9

< 0.00001

0

0.81

Fixed