Genome-wide methylation profiling of the bronchial mucosa of asthmatics: relationship to atopy

BMC Medical Genetics

Table 4 Gene ontology analysis of genes with different methylation states according to atopic status among BA

Methylation states	Category	Gene ontology category	Genes	Observed gene number	Expected gene number	Ratio of enrichment	Significance of enrichment
Hypomethylation	Biological process	Cellular hormone metabolic process	UGT1A1, CRYM, AKR1C4	3	0.21	14.37	0.001
		Positive regulation of DNA replication	PDGFC, UCN	2	0.08	25.06	0.003
		Response to organic substance	IL1R1, UGT1A1, UROS, CDH1, CASP1, NR1H4, UCN	7	1.97	3.55	0.003
		Porphyrin metabolic process	UGT1A1, UROS	2	0.09	23.27	0.003
		Multicellular organismal process	UGT1A1, PDGFC, KERA, C4orf6, CATSPER3, CRYM, RAG2, NR1H4,KALRN, PKHD1, CLCN5, UCN, CDH1, HOXA4, HOXA5, PDE4D, MMP13, CASP1, SLC6A2	19	10.87	1.75	0.004
		Monoamine transport	CRYM, SLC6A2	2	0.11	18.62	0.005
		Collagen metabolic process	MMP13, UCN	2	0.12	16.71	0.006
	Molecular function	Growth factor receptor binding	IL1R1, PDGFC, IL1F5	3	0.20	14.83	0.001
	Cellular component	Extrinsic to plasma membrane	GNB5, CDH1	2	0.14	14.75	0.008
Hypermethylation	Biological process	Signal transduction	MAP3K5, TACSTD2	2	0.13	15.73	0.005
		Immune response	RSAD2	1	0.05	14.96	0.001
		metabolic process	TIPARP	1	0.05	13.49	0.004
	Molecular function	Protein kinase activity	MAP3K5	1	0.04	22.48	0.002
		DNA binding	TIPARP	1	0.05	18.76	0.004
		Receptor activity	TACSTD2	1	0.03	14.64	0.009
	Cellular component	Cell surface receptor	TACSTD2	1	0.04	14.59	0.009

ISSN: 1471-2350