From: Genome-wide methylation profiling of the bronchial mucosa of asthmatics: relationship to atopy
Clinical profile | NC | Atopic asthmatics | Non atopic asthmatics | P-value | |
---|---|---|---|---|---|
NC vs BA | in BA | ||||
Number | 7 | 10 | 7 | Â | Â |
Age, years (range) | 50 (22–71) | 35 (21–60) | 47 (28–78) | 0.288 | 0.133 |
Sex, male, n(%) | 1 (14.3) | 4 (40) | 1 (14.3) | 0.629 | 0.338 |
exsmoker/nonsmoker (%) | 0 / 7 | 2 / 8 | 1 / 6 | 0.299 | 0.677 |
Positive skin test rate (%)* | ND | 100* | 0 | - | 0.00005 |
FVC (% predicted) | 89.20 ± 10.18 | 79.50 ± 16.89 | 90.80 ± 22.26 | 0.349 | 0.371 |
FEV1 (% predicted) | 102.00 ± 16.84 | 78.50 ± 22.54 | 90.60 ± 20.77 | 0.119 | 0.44 |
FEV1/FVC (% predicted) | 85.80 ± 6.18 | 77.00 ± 15.12 | 76.20 ± 6.10 | 0.168 | 0.513 |
Body mass index (kg/m2) | 23.37 ± 4.08 | 25.31 ± 1.66 | 25.92 ± 3.20 | 0.497 | 0.37 |
Total IgE (IU/M) | 37.2 | 663.95 ± 784.99 | 111.28 ± 99.90 | 0.267 | 0.036 |
Dp. specific IgE (score) | ND | 4 (2–6) | 0 | - | 0.0005 |
Df. specific IgE (score) | ND | 4 (2–6) | 0 | - | 0.0005 |