A genome-wide search for common SNP x SNP interactions on the risk of venous thrombosis

BMC Medical Genetics

Table 2 Interactive effects of the rs9804128 and rs4784379 on the risk of VT and on plasma FVIII levels

		EOVT		MARTHA		Combined		MARTHA patients⁽¹⁾
		Frequency		Frequency		Frequency		Frequency	Haplotypic FVIII expected mean [95%CI]
rs9804128	rs4784379	Controls	Cases	Controls	Cases	Controls	Cases
		N = 1,228	N = 411	N = 1,110	N = 1,542	N = 2,338	N = 1953
A	G	0.561	0.530	0.579	0.551	0.569	0.547	0.548	68.77 [66.27–71.26]
A	A	0.169	0.198	0.165	0.185	0.167	0.188	0.184	62.34 [58.03–66.64]
G	G	0.190	0.237	0.170	0.214	0.181	0.219	0.220	62.09 [56.35–67.83]
G	A	0.080	0.035	0.085	0.050	0.083	0.046	0.048	91.95 [92.98–100.9]
		p⁽²⁾ = 2.73 10^-5		p⁽²⁾ = 9.45 10^-6		p⁽³⁾ = 1.90 10^-9			p⁽⁴⁾ = 6.89 10^-5

⁽¹⁾ In MARTHA, 1091 patients were measured for FVIII levels.
⁽²⁾ p-value of the interaction term between the two SNPs in the logistic regression analysis under the assumption of additive allele effects.
⁽³⁾ p-value obtained from the meta-analysis of the EOVT and MARTHA samples using a fixed-effect model.
⁽⁴⁾ p-value of the interaction term between the two SNPs in the linear regression analysis, adjusted for age, sex, ABO blood group and F5/F2 carriers mutations.

ISSN: 1471-2350