The CARD8 p.C10X mutation associates with a low anti-glycans antibody response in patients with Crohn’s disease

BMC Medical Genetics

Table 2 Results of familial QTDT analyses including the whole population (n=200)

	Adjusted by the CD status		Adjusted by the CD status, and NOD2and NOD1genotypes
	p value	Z for mutated allele	p value	Z for mutated allele
ASCA level	0.024	−24.59	0.023	−24.58
ASCA binary trait (positive/negative)	0.05	−0.146	0.05	−0.145
ALCA level	0.0035	−17.08	0.0034	−17.17
ALCA binary trait (positive/negative)	0.0025	−0.232	0.0026	−0.230

The Z values reflect the strength of associations; negatives values reflect an association with a lower level of the trait under study. Positive values would reflect association with a higher level of the trait. NOD2, (R702W, G908R, 1007fs insC mutations) and the NOD1 +32656 genotypes were from Vasseur et al. [30].

ISSN: 1471-2350