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Table 1 Allelic frequencies of the p.C10X mutation in the populations under study

From: The CARD8 p.C10X mutation associates with a low anti-glycans antibody response in patients with Crohn’s disease

   p.C10X MAF 95% CI Comparison between the 4 groups (dof=3) Comparison (dof=1) Comparison (dof=1)
1 CD patients 0.243 [0.183-0.316] p = 0.09 1 vs. 2 1+2 vs. 3+4
2 Healthy subjects from CD families 0.238 [0.177-0.309]    
      p=0.89  
       p = 0.06
3 French control families 0.347 [0.251-0.471]   3 vs. 4  
      p = 0.53  
4 HapMap CEU 0.315 [0.271-0.361]    
  1. Frequencies are those determined in pedigrees using the Haploview software. All frequencies comparisons were performed with the CLUMP software and robust p values were obtained following 100,000 Monte Carlo permutations. (MAF: minor allele frequency, dof: degree of freedom).