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Figure 2 | BMC Medical Genetics

Figure 2

From: The CARD8 p.C10X mutation associates with a low anti-glycans antibody response in patients with Crohn’s disease

Figure 2

Measurement of anti-glucan antibody levels in human sera according to p. C10X genotype. Anti-glucan antibody (ALCA) levels were determined in sera from CD probands (A) and healthy first-degree relatives (B) by ELISA. Antibody titers (expressed in AU according to the reactivity of the manufacturer’s calibrator) in samples from subjects who were wild-type (C/C), heterozygous (C/X), or homozygous (X/X) for the p.C10X mutation. Positive or negative ALCA status was determined according to the cutoff value of 60 AU determined according to the manufacturer's instruction.

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