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Table 1 Estimated haplotype distributions for selected D-amino acid oxidase (DAO), protein phosphatise 3 catalytic subunit gamma isoform (PPP3CCC) and dystrobrevin-binding protein 1 (DTNBP1) single nucleotide polymorphisms in patients with schizophrenia and control subjects and in females and males samples

From: Schizophrenia susceptibility and NMDA-receptor mediated signalling: an association study involving 32 tagSNPs of DAO, DAOA, PPP3CC, and DTNBP1genes

DAO Haplotype (rs2070586|rs3741775)

 

Haplotype

Patientsa

Controlsb

χ 2

DF

P

P correctc

Total samples

 

N = 386

N = 476

    
 

GG

0.42

0.40

0.69

1

0.41

 
 

AT

0.21

0.19

1.40

1

0.24

 
 

GT

0.37

0.41

3.70

1

0.05

0.13

Females

 

N = 126

N = 270

    
 

GG

0.43

0.39

1.31

1

0.25

 
 

AT

0.23

0.17

3.88

1

0.05

0.11

 

GT

0.33

0.44

8.65

1

0.003

0.009

Males

 

N = 260

N = 206

    
 

GG

0.41

0.41

0.01

1

0.92

 
 

AT

0.20

0.21

0.10

1

0.75

 
 

GT

0.39

0.38

0.03

1

0.86

 

PPP3CC Haplotype (rs4872499|rs11780915|rs13271367)

 

Haplotype

Patients a

Controls b

χ 2

DF

P

P correct c

Total samples

 

N = 383

N = 476

    
 

CGA

0.61

0.56

3.50

1

0.06

 
 

TAG

0.22

0.21

0.62

1

0.43

 
 

CAG

0.13

0.19

11.56

1

7x10-4

0.001

 

others

0.03

0.03

    

Females

 

N = 125

N = 269

    
 

CGA

0.60

0.57

0.63

1

0.43

 
 

TAG

0.22

0.17

2.65

1

0.10

 
 

CAG

0.12

0.20

7.60

1

0.006

0.04

 

others

0.05

0.05

    

Males

 

N = 258

N = 207

    
 

CGA

0.61

0.55

3.52

1

0.06

 
 

TAG

0.22

0.25

1.14

1

0.29

 
 

CAG

0.13

0.17

2.98

1

0.08

 
 

others

0.03

0.02

    

DTNBP1 Haplotype (rs6459409|rs9476886)

Total samples

 

N = 381

N = 473

    
 

CT

0.17

0.20

2.18

1

0.14

 
 

TT

0.13

0.12

0.78

1

0.38

 
 

TC

0.69

0.68

0.28

1

0.60

 

Females

 

N = 125

N = 270

    
 

CT

0.20

0.17

0.62

1

0.43

 
 

TT

0.15

0.12

1.23

1

0.27

 
 

TC

0.65

0.70

1.84

1

0.17

 

Males

 

N = 256

N = 203

    
 

CT

0.16

0.24

8.55

1

0.003

0.006

 

TT

0.12

0.11

0.34

1

0.56

 
 

TC

0.71

0.65

3.77

1

0.05

0.14

  1. ahaplotype frequencies in schizophrenia patients.
  2. bhaplotype frequencies in control subjects.
  3. DF = degree of freedom.
  4. cPcorrect after 10000 permutations.