From: NQO1 C609T polymorphism and esophageal cancer risk: a HuGE review and meta-analysis
Ref. | Investigator | Year | Country | Race | Eligible subjects | Characteristic | Source of controls | Method | ||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Cases | Controls | ESCC | EAC | Cases | Controls | |||||||
[25] | Hamajima et al. | 2002 | Japan | Asian | 102 | 241 | * | * | The patients were invited to participate in the present study by doctors in charge. They were enrolled between March 1999 and December 2000 at Aichi Cancer Center Hospital. | Controls were sampled from patients at Aichi Cancer Center Hospital during the same period as for the cases; participants in a Helicobacter pylori eradication program without a history of cancer who underwent gastroscopy. | Hospital-based | PCR-CTPP |
[27] | Sarbia et al. | 2003 | Germany | Caucasian | 61 | 252 | 0 | 61 | Patients who underwent oesophagectomy for oesophageal adenocarcinoma between 1987 and 2001. | Healthy blood donors of the Heinrich Heine University Blood Donation Centre between 1995 and 2001. They were from the same geographic region as case groups but were unrelated. | Population -based | PCR-RFLP |
[29] | Zhang JH et al. | 2003 | Germany | Caucasian | 257 | 252 | 257 | 0 | All ESCC patients that underwent esophagectomy without prior radio- and/or chemotherapy between 1978 and 1998 in the Department of Surgery of the Heinrich Heine University, Duesseldorf. | The healthy controls from the German Caucasian population were unrelated blood donors from the same region as the ESCC patients. | Population-based | PCR-RFLP |
[30] | Zhang JH et al. | 2003 | China | Asian | 317 | 306 | 193 | 124 | All ESCC patients that underwent esophagectomy without prior radio- and/or chemotherapy between 2001 and 2002 in the Fourth Affiliated Hospital, Hebei Medical University. | The healthy controls from the northern Chinese population were unrelated blood donors from the same region as the ESCC patients. | Population-based | PCR-RFLP |
[28] | Rahden et al. | 2005 | Germany | Caucasian | 140 | 260 | 0 | 140 | The patients that underwent esophagectomy without prior radio- or chemotherapy between 1991–2003 at the Technical University of Munich. | Healthy volunteers subjects hospitalized for traumatic injuries but without any history of cancer. | Hospital-based | PCR |
[31] | Zhang WC et al. | 2006 | China | Asian | 106 | 106 | * | * | The patients were diagnosed for primary esophageal cancer by pathology or endoscopy between 2003–2004, they were Han Chinese person. | The healthy controls from the same region without digestive system disease and any history of cancer. | Hospital-based | PCR-RFLP and ASPCR |
[24] | Martino et al. | 2007 | UK | Caucasian | 141 | 93 | 0 | 141 | The patients were diagnosed based on endoscopic and histological evidence. | Control individuals had been recruited from a dyspepsia endoscopy list, 44 of these (47%) reported reflux-related symptoms, such as heartburn and/or regurgitation. | Hospital-based | PCR-RFLP |
[26] | Marjani et al. | 2010 | Iran | Caucasian | 93 | 50 | 93 | 0 | The criteria for enrollment patients were an age of at least 18 years and be resident of the study area at registration time, with no concurrent or previous history of other cancer in any organ. | Controls with no malignancy and/or severe diseases, were enrolled between the years 2002 and 2008, with the same age and residence criteria as for the cases. | Hospital-based | PCR-RFLP |