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Table 4 Interaction effect of obesity on the association between MMP1 genotypes and MMP1 levels

From: Genetic variants associated with circulating MMP1 levels near matrix metalloproteinase genes on chromosome 11q21-22 in Taiwanese: interaction with obesity

 

Non-obese

Obese

SNP

N

Coefficient

SE

t value

P value

N

Coefficient

SE

t value

P value

Interaction P

rs11226373

322

−0.1193

0.0543

−2.1944

0.029

186

0.0305

0.0696

0.4374

0.662

0.100

rs1799750

320

0.1844

0.0402

4.5816

6.66x10-6

186

0.0041

0.0539

0.0752

0.940

0.008

rs1144393

323

0.0324

0.0741

0.4368

0.663

186

0.1128

0.0937

1.2039

0.230

0.536

rs514921

323

0.0097

0.0600

0.1623

0.871

185

0.0147

0.0897

0.1642

0.870

0.983

rs495366

321

0.1630

0.0393

4.1443

4.38x10-5

186

0.0689

0.0472

1.4608

0.146

0.119

  1. Additive genetic model; Coefficients and P values were performed using the linear regression model under the assumption of an additive effect of the minor allele; adjusted for age, sex, and smoking.
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BMC Medical Genetics

ISSN: 1471-2350

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