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Table 2 Association between clinical characteristics and suboptimal 25-hydroxyvitamin D3 levels at time of diagnosis in melanoma patients

From: Serum 25-hydroxyvitamin D3 levels and vitamin D receptor variants in melanoma patients from the Mediterranean area of Barcelona

  Variables*   VitD level sufficient >25 ng/mL n = 26(32%) VitD level insufficient ≤25 ng/mL n = 55(68%) OR (95%IC) P
Clinical characteristic Age at diagnosis of melanoma**   54 (36–65) 55 (37–68) 0.99 (0.96- 1.01) 0.553
  Gender Female 15 (57.7%) 23 (41.8%) 1  
   Male 11 (42.3%) 32 (58.2%) 1.9 (0.74- 4.88) 0.184
  BMI basal (kg/m2) Normal weight 9 (47.4%) 15 (34.1%) 1  
   Overweight 6 (31.6%) 18 (40.9%) 0.56 (0.16- 1.92) 0.353
   Obese 4 (21.1%) 11 (25%) 0.61 (0.16- 2.49) 0.487
  Season blood sampling Spring- Summer 18 (69.2%) 20 (38.5%) 1  
   Autumn- Winter 8 (30.8%) 32 (61.5%) 3.6 (1.32- 9.81) 0.012
  Fitzpatrick skin type Dark 16 (61.5%) 21 (38.2%) 1  
   Fair 10 (38.5%) 34 (61.8%) 2.59 (0.99- 6.76) 0.052
  Hair color Dark 8 (30.8%) 32 (61.5%) 1  
   Light 8 (32%) 15 (29.4%) 0.89 (0.32- 2.49) 0.818
  Eye color Dark 11 (44%) 27 (54%) 1  
   Light 14 (56%) 23 (46%) 0.67 (0.26- 1.76) 0.415
  Actinic damage No 21 (80.8%) 41 (78.8%) 1  
   Yes 5 (19.2%) 11 (21.2%) 0.89 (0.27- 2.89) 0.843
  Nevus Number <50 12 (54.5%) 22 (53.7%) 1  
   ≥50 10 (45.5%) 19 (46.3%) 0.97 (0.34- 2.73) 0.946
Habits of solar exposure and photoprotection Solar exposure before 10 years old Severe/Moderate 21 (80.8%) 38 (73.1%) 1  
   None/Mild 5 (19.2%) 14 (26.9%) 1.55 (0.49- 4.9) 0.458
  Solar exposure 10–18 years old Severe/Moderate 23 (88.5%) 34 (66.7%) 1  
   None/Mild 3 (11.5%) 17(33.3%) 3.83 (1.01- 14.5) 0.049
  Solar exposure > 18 years old Severe/Moderate 11 (91.7%) 18 (64.3%) 1  
   None/Mild 1 (8.3%) 10 (35.7%) 6.11 (0.68- 54.5) 0.105
  Photoprotection before 10 years old Never 17 (68%) 30 (63.8%) 1  
   Usually 8 (32%) 17 (36.2%) 1.20 (0.43- 3.37).33) 0.724
  Photoprotection 10–18 years old Never 14 (73.3%) 19 (63.3%) 1  
   Usually 5 (26,3%) 11 (36.7%) 1.62 (0.46- 5.73) 0.453
  Photoprotection over 18 years old Never 15 (60%) 21 (45.7%) 1  
   Usually 10 (40%) 25 (54.3%) 1.79 (0.66- 4.80) 0.250
Melanoma characteristic Number of Melanoma SPM 24 (92.3%) 49 (89.1%) 1  
   MPM 2 (7.7%) 6 (10.9%) 0.68 (0.13- 3.63) 0.652
  Breslow thickness+ <= 0.75 22 (46.8%) 9 (42.9%) 1  
   0.75-1 11 (23.4%) 4 (19.0%) 0.89 (0.22- 3.54) 0.867
   > = 1 14 (29.8%) 8 (38.1) 1.4 (0.43- 4.48) 0.574
  Breslow thickness+**   0.8 (0.52- 1.3) 0.8 (0.52- 1.2) 1.1 (0.78- 1.54) 0.583
  1. VitD = 25-hydroxyvitamin D3 *Not all the patients have complete data +Breslow thickness was analized as categorical and continuos variable **The medians (25th - 75th percentiles) of 25-hydroxyvitamin D3 levels were reported for age at diagnosis of melanoma and breslow thickness.