Table 2 Association between clinical characteristics and suboptimal 25-hydroxyvitamin D3 levels at time of diagnosis in melanoma patients
Variables* | VitD level sufficient >25 ng/mL n = 26(32%) | VitD level insufficient ≤25 ng/mL n = 55(68%) | OR (95%IC) | P | ||
|---|---|---|---|---|---|---|
Clinical characteristic | Age at diagnosis of melanoma** | 54 (36–65) | 55 (37–68) | 0.99 (0.96- 1.01) | 0.553 | |
Gender | Female | 15 (57.7%) | 23 (41.8%) | 1 | ||
Male | 11 (42.3%) | 32 (58.2%) | 1.9 (0.74- 4.88) | 0.184 | ||
BMI basal (kg/m2) | Normal weight | 9 (47.4%) | 15 (34.1%) | 1 | ||
Overweight | 6 (31.6%) | 18 (40.9%) | 0.56 (0.16- 1.92) | 0.353 | ||
Obese | 4 (21.1%) | 11 (25%) | 0.61 (0.16- 2.49) | 0.487 | ||
Season blood sampling | Spring- Summer | 18 (69.2%) | 20 (38.5%) | 1 | ||
Autumn- Winter | 8 (30.8%) | 32 (61.5%) | 3.6 (1.32- 9.81) | 0.012 | ||
Fitzpatrick skin type | Dark | 16 (61.5%) | 21 (38.2%) | 1 | ||
Fair | 10 (38.5%) | 34 (61.8%) | 2.59 (0.99- 6.76) | 0.052 | ||
Hair color | Dark | 8 (30.8%) | 32 (61.5%) | 1 | ||
Light | 8 (32%) | 15 (29.4%) | 0.89 (0.32- 2.49) | 0.818 | ||
Eye color | Dark | 11 (44%) | 27 (54%) | 1 | ||
Light | 14 (56%) | 23 (46%) | 0.67 (0.26- 1.76) | 0.415 | ||
Actinic damage | No | 21 (80.8%) | 41 (78.8%) | 1 | ||
Yes | 5 (19.2%) | 11 (21.2%) | 0.89 (0.27- 2.89) | 0.843 | ||
Nevus Number | <50 | 12 (54.5%) | 22 (53.7%) | 1 | ||
≥50 | 10 (45.5%) | 19 (46.3%) | 0.97 (0.34- 2.73) | 0.946 | ||
Habits of solar exposure and photoprotection | Solar exposure before 10 years old | Severe/Moderate | 21 (80.8%) | 38 (73.1%) | 1 | |
None/Mild | 5 (19.2%) | 14 (26.9%) | 1.55 (0.49- 4.9) | 0.458 | ||
Solar exposure 10–18 years old | Severe/Moderate | 23 (88.5%) | 34 (66.7%) | 1 | ||
None/Mild | 3 (11.5%) | 17(33.3%) | 3.83 (1.01- 14.5) | 0.049 | ||
Solar exposure > 18 years old | Severe/Moderate | 11 (91.7%) | 18 (64.3%) | 1 | ||
None/Mild | 1 (8.3%) | 10 (35.7%) | 6.11 (0.68- 54.5) | 0.105 | ||
Photoprotection before 10 years old | Never | 17 (68%) | 30 (63.8%) | 1 | ||
Usually | 8 (32%) | 17 (36.2%) | 1.20 (0.43- 3.37).33) | 0.724 | ||
Photoprotection 10–18 years old | Never | 14 (73.3%) | 19 (63.3%) | 1 | ||
Usually | 5 (26,3%) | 11 (36.7%) | 1.62 (0.46- 5.73) | 0.453 | ||
Photoprotection over 18 years old | Never | 15 (60%) | 21 (45.7%) | 1 | ||
Usually | 10 (40%) | 25 (54.3%) | 1.79 (0.66- 4.80) | 0.250 | ||
Melanoma characteristic | Number of Melanoma | SPM | 24 (92.3%) | 49 (89.1%) | 1 | |
MPM | 2 (7.7%) | 6 (10.9%) | 0.68 (0.13- 3.63) | 0.652 | ||
Breslow thickness+ | <= 0.75 | 22 (46.8%) | 9 (42.9%) | 1 | ||
0.75-1 | 11 (23.4%) | 4 (19.0%) | 0.89 (0.22- 3.54) | 0.867 | ||
> = 1 | 14 (29.8%) | 8 (38.1) | 1.4 (0.43- 4.48) | 0.574 | ||
Breslow thickness+** | 0.8 (0.52- 1.3) | 0.8 (0.52- 1.2) | 1.1 (0.78- 1.54) | 0.583 |