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Table 1 Core phenotyping in DIACORE

From: Study design of DIACORE (DIAbetes COhoRtE) – a cohort study of patients with diabetes mellitus type 2

Phenotype category

Item

Instrument for obtaining phenotype

General

Current Medication

Q

Ethnicity

Q*

Health insurance

Q

Disease management program

Q

Fasting status

Q

Birth weight

Q*

Anthropometry

Systolic and diastolic blood pressure

P

Heart rate

P

Height

P

Weight

P

 

Waist circumference

P

Hip circumference

P

Risk factors

Diabetes duration

Q*

Hypertension duration

Q*

Smoking history

Q

Lipid status

L

Physical activity

Q

Family history of kidney disease

Q

Morbidity

CAD

Q

 

History of CAD (WHO Rose Angina Questionnaire)

Q

 

Myocardial infarction

Q#

 

CABG, PCI, heart valve surgery

Q#

 

PAD and carotid atherosclerosis

 
 

History of PAD (Edinburgh Questionnaire)

Q

 

Vascular surgery or percutaneous intervention in peripheral and carotid vessels

Q#

 

Cerebral ischemia

Q#

 

Microangiopathy

 
 

History of kidney disease and biopsy results

Q#

 

Kidney function parameters (e.g. eGFR, annual eGFR decline, albuminuria, change in albuminuria over time, dipstick urine proteinuria)

L

 

Time to doubling of serum creatinine

 

Time to incident renal replacement therapy

Q#§

 

Diabetic retinopathy requiring laser therapy

Q#

 

History of malignancy

Q#

 

Hospitalisation

Q#§

 

Mortality including cause

Q#§

  1. CAD: Coronary artery disease. PAD: peripheral artery disease. Q: self-reported information obtained by questionnaire. L: obtained by laboratory analysis of biosamples. P: obtained by physical examination.
  2. * item determined at baseline visit only.
  3. # items validated by obtaining medical records.
  4. § item determined at follow-up visits only.