Skip to main content

Table 3 Results of the genetic association analyses for log e (CAC score + 1) using Metabochip SNPs (additive genetic model) and age as predictors in a linear regression model for females and males

From: Risk loci for coronary artery calcification replicated at 9p21 and 6q24 in the Heinz Nixdorf Recall Study

CHR Gene SNP Physical position Gender-SNP Interaction Females Males  
     Beta (95% CI) P Beta (95% CI) P Beta (95% CI) P
9 CDKN2A/2B rs1537373 22093341 −0.07 (−0.25 to 0.11) 0.44 0.27 (0.15-0.39) 1.28x10-5 0.34 (0.21-0.47) 6.76x10-7
   rs10965219 22043687 −0.23 (−0.41 to -0.06) 0.01 0.13 (0.01-0.26) 0.03 0.36 (0.23-0.50) 1.25x10-7
6 PHACTR1 rs9349379 13011943 0.08 (−0.01 to 0.27) 0.37 0.35 (0.23-0.48) 3.5x10-8 0.27 (0.14-0.41) 7.58x10-5
  1. CHR Chromosome number; SNP single nucleotide polymorphism; MAF minor allele frequency from our data; 95% CI 95% confidence interval; CAC coronary artery calcium.