Table 3 Results of the genetic association analyses for log e (CAC score + 1) using Metabochip SNPs (additive genetic model) and age as predictors in a linear regression model for females and males
CHR | Gene | SNP | Physical position | Gender-SNP Interaction | Females | Males | |||
|---|---|---|---|---|---|---|---|---|---|
Beta (95% CI) | P | Beta (95% CI) | P | Beta (95% CI) | P | ||||
9 | CDKN2A/2B | rs1537373 | 22093341 | −0.07 (−0.25 to 0.11) | 0.44 | 0.27 (0.15-0.39) | 1.28x10-5 | 0.34 (0.21-0.47) | 6.76x10-7 |
rs10965219 | 22043687 | −0.23 (−0.41 to -0.06) | 0.01 | 0.13 (0.01-0.26) | 0.03 | 0.36 (0.23-0.50) | 1.25x10-7 | ||
6 | PHACTR1 | rs9349379 | 13011943 | 0.08 (−0.01 to 0.27) | 0.37 | 0.35 (0.23-0.48) | 3.5x10-8 | 0.27 (0.14-0.41) | 7.58x10-5 |