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Table 2 Results of the genetic association analyses for log e (CAC score + 1) using Metabochip SNPs (additive genetic model), gender and age as predictors in a linear regression model

From: Risk loci for coronary artery calcification replicated at 9p21 and 6q24 in the Heinz Nixdorf Recall Study

CHR Gene SNP Physical position Minor allele (MAF) loge(CAC score + 1) loge(CAC +1) without CHD dichotomized CAC
      Beta (95% CI) P Beta (95% CI) P OR (95% CI) P
9 CDKN2A/2B rs1537373 22093341 G (0.47) 0.30 (0.21-0.39) 4.05x10-11 0.26 (0.17-0.35) 1.52x10-8 1.19 (1.07-1.31) 0.001
   rs10965219 22043687 G (0.48) 0.25 (0.16-0.39) 1.32x10-7 0.23 (0.14-0.32) 1.28x10-6 1.16 (1.05-1.29) 0.005
6 PHACTR1 rs9349379 13011943 G (0.39) 0.30 (0.22-0.40) 4.67x10-11 0.31 (0.22-0.40) 3.48x10-11 1.26 (1.14-1.4) 1.47x10-5
  1. CHR Chromosome number; SNP single nucleotide polymorphism; MAF minor allele frequency from our data; 95% CI 95% confidence interval; CAC coronary artery calcium and CHD coronary heart disease.