Analysis of the contribution of FTO, NPC1, ENPP1, NEGR1, GNPDA2 and MC4Rgenes to obesity in Mexican children

Table 2 Association between SNPs MC4R rs17782313, NEGR1 rs2815752, ENPP1 rs7754561, NPC1 rs1805081, GNPDA2 rs10938397 and FTO rs1421085, and obesity in Mexican children

Locus	SNP	RA*	Cases/	N	RAF	OR	P
Locus	SNP	RA*	Controls	N	(%)	[95% CI]	P
			Lean children	949	74.4	-	-
*NEGR1*	rs2815752	A
			Obese children	514	77.6	1.18 [0.99;1.41]	0.068
			Lean children	949	74.6	-	-
*NPC1*	rs1805081	A
			Obese children	514	74.2	1.02 [0.85;1.21]	0.845
			Lean children	949	48.6	-	-
*ENPP1*	rs7754561	G
			Obese children	514	44.2	0.84 [0.72;0.97]	0.020
			Lean children	949	7.3	-	-
*MCR4*	rs17782313	C
			Obese children	514	9.8	1.40 [1.06;1.83]	0.016
			Lean children	949	32.2	-	-
*GNPDA2*	rs10938397	G
			Obese children	514	38.0	1.30 [1.11;1.53]	1.34 × 10 ^-3
			Lean children	949	19.1	-	-
*FTO*	rs1421085	C
			Obese children	514	21.1	1.13 [0.93;1.38]	0.228

*We noted the risk-alleles reported in European populations.
RA, risk-allele; RAF, risk-allele frequency; OR, odds ratio; CI, confidence interval; P, P-Value.

ISSN: 1471-2350