Cohort 1 AmpliChip | Comparison | Cohort 2 AmpliChip | Comparison | PCR-RFLP | Dandara et al. 2001 | Dandara et al. 2011 [32] | Drögemöller et al. 2010 | Ikediobi et al. 2011 [33] | Matimba et al. 2009 | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Allele | Activity | Black African | White Caucasian | Coloured | Indian | Fischer's Exact | Black African | White Caucasian | Coloured | Indian | Fischer's Exact | Black African | White Caucasian | Coloured | Indian | SA Venda | SA Bt20 (mixed Black) | SA Xhosa | SA Coloured | SA Xhosa | SA Coloured | SA Venda |
Allele Frequency (%) | ||||||||||||||||||||||
*1+ | Normal | 85.7 | 75.0 | 75.0 | 60.0 | 1.000 | 82.1 | 95.0 | 65.0 | 65.0 | 0.000 | 32.1 | 70.0 | 40.0 | 40.0 | 78.0 | 23.0 | 17.0 | 41.0 | 63.0 | 71.0 | 77.0 |
*2 | Absent | 116 | 25.0 | 25.0 | 40.0 | 0.784 | 17.9 | 5.0 | 35.0 | 35.0 | 1.000 | 17.9 | 5.0 | 35.0 | 35.0 | 22.0 | 61.0 | 21.0 | 17.0 | 22.0 | 20.0 | 17.0 |
*3 | Absent | 2.7 | 0.0 | 0.0 | 0.0 | 0.084 | 0.0 | 0.0 | 0.0 | 0.0 | 1.000 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 16.0 | 0.0 | 7.0 | - | - | 0.0 |
*9 | Decreased | - | - | - | - | - | - | - | - | - | 0.058 | 3.6 | 0.0 | 0.0 | 0.0 | - | - | 9.0 | 4.0 | - | - | 6.0 |
*15 | Unknown | - | - | - | - | - | - | - | - | - | 0.002 | 5.7 | 0.0 | 10.0 | 0.0 | - | - | 9.0 | 8.0 | - | - | 0.0 |
*17 | Increaased | - | - | - | - | - | - | - | - | - | 0.000 | 16.4 | 25.0 | 0.0 | 5.0 | - | - | 10.0 | 14.0 | 15.0 | 9.0 | - |
*27 | Decreased | - | - | - | - | - | - | -- | - | 0.000 | 24.3 | 0.0 | 15.0 | 20.0 | - | - | 33.0 | 8.0 | - | - | - | |
*28 | Unknown | - | - | - | - | - | - | - | - | - | 1.000 | 0.0 | 0.0 | 0.0 | 0.0 | - | - | 1.0 | 1.0 | - | - | 0.0 |
Alleles identified (n) | 112.0 | 12.0 | 20.0 | 20.0 | 140.0 | 20.0 | 20.0 | 20.0 | 140.0 | 20.0 | 20.0 | 20.0 | 152.0 | 1964-1970 | 200.0 | 150.0 | 218.0 | 134.0 | 18.0 | |||
Predicted Phenotype Frequency (%) | ||||||||||||||||||||||
PM | 3.5 | 16.7 | 10.0 | 30.0 | 7.1 | 0.0 | 10.0 | 10.0 | 5.7 | 0.0 | 20.0 | 50.0 | 5.3 | 1.5 | 3.0 | 8.0 | - | - | - | |||
IM | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 21.4 | 10.0 | 50.0 | 40.0 | 32.9 | 13.0 | 49.0 | 40.0 | - | - | - | |||
EM | 94.7 | 83.3 | 90.0 | 70.0 | 92.9 | 100.0 | 90.0 | 90.0 | 45.7 | 90.0 | 30.0 | 0.0 | 61.6 | 85.5 | 39.0 | 35.0 | - | - | - | |||
UM | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 27.1 | 0.0 | 0.0 | 10.0 | 0.0 | 0.0 | 9.0 | 17.0 | - | - | - | |||
Failure | 1.8 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 1.1-0.8 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | |||
Cohort (n) | 57 | 6 | 10 | 10 | 70 | 10 | 10 | 10 | 70 | 10 | 10 | 10 | 76 | 982-985 | 100 | 75 | 109 | 67 | 9 |