Table 2 CYP2D6 and CYP2C19 phenotype prediction
Estimated metabolic potential of alleles | |||
|---|---|---|---|
CYP2D6 | Allele activity | Numeric activity | CYP2C19 |
*1xN, *2xN | Increased | 2.0 | *17 |
*1,*2, *22, *33, *35, *43, *45B, *46 | Normal | 1.0 | *1+, *28 |
*10, *17, *29, *41, *59 | Decreased | 0.5 | *9, *27 |
*4, *5, *14, *16, *40, *56B, *4xN | Absent | 0.0 | *2, *3 |
*25, *30, *64, *65, *73, *74, *84, *85, *86 | Unknown | 1.0 | *15 |
(Activity according to http://www.cypalleles.ki.se/) | |||
Phenotype prediction | |||
AmpliChip | Prediction | Activity Score (AS) | |
3 or more functional alleles | UM | > 2.0 | |
1 or 2 functional alleles and increased paired with decreased or absent | EM | 1.5-2.0 | |
1 or 2 reduced function alleles | IM | 0.5-1.0 | |
2 absent function alleles | PM | 0.0 | |