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Table 1 Summary of reported CYP2D6 genotyping studies using the AmpliChip CYP450 test

From: Introduction of the AmpliChip CYP450 Test to a South African cohort: a platform comparative prospective cohort study

Article

Nikoloff et al. 2002

Ishida et al. 2002

Heller et al. 2006

Rebsamen et al. 2009

de Leon et al. 2009

Ramόn y Cajal et al. 2010

Cohort

TD+ Schizophrenic Koreans

TD- Schizophrenic Koreans

Japanese

German Caucasians

Swiss female Caucasians

American Caucasians

African Americans

Tamoxifen treated Spanish Caucasians

Variant

Allele frequency (%)

*1

38.2

40.7

46.9

36.2

35.5

37.4

59.7

35.7

*2

9.1

9.2

19.8

10.5

15.5

15.9

6.0

16.5

*3

0.0

0.0

0.0

3.0

0.6

1.8

0.2

0.5

*4

0.0

0.0

0.0

12.2

20.6

21.0

5.5

14.8

*5

3.6*

1.6*

-

8.2

2.4

2.3

2.8

4.9

*6

0.0

0.0

0.0

2.6

1.2

1.1

0.2

0.5

*7

0.0

0.0

0.0

0.0

0.3

0.0

0.0

0.0

*8

0.0

0.0

0.0

0.0

0.0

0.0

0.0

0.0

*9

0.0

0.0

0.0

0.7

2.7

2.9

0.4

7.1

*10

47.3

46.1

33.3

1.6

2.7

1.0

3.8

4.4

*11

0.0

0.0

0.0

0.0

0.0

0.0

0.0

0.0

*14

0.5

0.0

0.0

0.0

0.0

0.0

0.0

0.0

*15

-

-

-

0.0

0.0

0.0

0.0

0.0

*17

-

-

-

0.0

0.3

0.3

18.4

0.0

*18

0.0

0.0

0.0

0.0

0.0

0.0

0.0

0.0

*19

0.0

0.0

0.0

0.0

0.0

0.0

0.0

0.0

*20

-

-

-

0.0

0.0

0.0

0.0

0.5

*25

0.0

0.0

0.0

0.0

0.0

0.0

0.0

0.0

*26

0.0

0.0

0.0

0.0

0.0

0.0

0.0

0.0

*29

-

-

-

0.0

0.3

0.2

7.7

0.0

*30

-

-

-

0.0

0.0

0.0

0.0

0.0

*31

0.0

0.0

0.0

0.0

0.0

0.0

0.0

0.0

*35

-

-

-

6.6

7.3

4.8

0.9

4.4

*36

0.0*

0.0*

-

0.0

0.0

0.0

0.6

0.0

*40

-

-

-

0.0

0.0

0.0

0.3

0.0

*41

1.4

2.2

0.0

6.3

7.3

9.8

14.9

9.3

*1xn

-

-

-

6.6

0.6

0.7

0.8

0.5

*2xn

-

-

-

4.9

1.5

0.5

1.2

0.5

*4xn

-

-

-

0.3

0.3

0.1

2.4

0.0

*6xn

-

-

-

0.0

0.0

0.0

0.0

0.0

*10xN

-

-

-

0.0

0.0

0.0

0.0

0.0

*17xN

-

-

-

0.0

0.0

0.0

0.2

0.0

*29xN

-

-

-

0.0

0.0

0.0

0.2

0.0

*35xN

-

-

-

0.3

0.0

0.0

0.0

0.0

*41xN

-

-

-

0.0

0.9

0.1

0.0

0.0

Total alleles

220

184

162

304

330

7558

904

182

Predicted phenotype

PM

0 (0.0)

0 (0.0)

Not reported

10.5 (16)

9.1 (15)

8.2 (311)

1.8 (8)

6.6 (6)

IM

23.6 (26)

25 (23.0)

4.0 (6)

7.9 (13)

9.7 (365)

32.7 (148)

11.0 (10)

EM

76.4 (84)

75 (69.0)

71.7 (109)

81.8 (135)

80.7 (3048)

63.5 (287)

81.3 (74)

UM

-

-

13.8 (21)

1.2 (2)

1.5 (55)

2.0 (9)

1.1 (1)

Cohort

110

92

81

152

165

3779

452

91

  1. Alleles not covered by AmpliChip at the time of reporting are represented by “—”. The microarray used in the Nikoloff et al. (2002) paper did not cover CYP2D6*5; however, a separate assay was used for *5 detection and the frequency was reported. Predicted phenotype reported or adjusted to represent AmpliChip test calls. TD+; patients with tardive dyskinesia, TD- patients without tardive dyskinesia.
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BMC Medical Genetics

ISSN: 1471-2350

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