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Table 3 Sharing of adiponectin Q haplotypes by cardiovascular risk traits

From: The 3′-UTR of the adiponectin Q gene harbours susceptibility loci for atherosclerosis and its metabolic risk traits

SNP block Haplotype Trait Pooled Controls Cases χ2 P-value
1-8 GTGCCTCA MI 0.025 0.022 0.029 4.13 0.042
   HTN 0.025 0.021 0.029 6.40 0.011**
   OBS 0.024 0.020 0.027 5.18 0.023*
1-7 GTGCCTC CAD 0.025 0.021 0.030 7.17 0.007**
   MI 0.025 0.023 0.030 4.41 0.036
   HTN 0.025 0.021 0.030 7.17 0.007**
   OBS 0.025 0.020 0.028 6.19 0.013**
1-6 GTGCCT MI 0.025 0.023 0.030 4.40 0.036
   HTN 0.025 0.021 0.030 7.19 0.007**
   OBS 0.025 0.020 0.028 5.51 0.019**
1-5 GTGCC MI 0.027 0.025 0.032 4.86 0.028
   HTN 0.027 0.023 0.032 6.46 0.011**
   OBS 0.026 0.022 0.029 4.22 0.040
1-4 GTGC MI 0.028 0.025 0.033 5.06 0.025
   HTN 0.028 0.023 0.032 6.60 0.010**
   OBS 0.027 0.023 0.030 4.19 0.041
5-8 TCCA OBS 0.025 0.029 0.022 4.95 0.026
   lHDL 0.025 0.021 0.029 5.06 0.025
  1. The table lists some of the shared haplotypes constructed from the studied variants, rs224176 (1), rs6444174 (2), rs6773957 (3), rs1063537 (4), rs2082940 (5), rs4686804 (6), rs1063539 (7) and rs9842733 (8), arranged sequentially by their chromosomal positions. The most frequent 8-mer haplotype TTACCCCA (0.344) was employed as the baseline to determine the relative effects of these haplotypes. The pooled, control and case haplotype frequencies are proportions. SNP blocks represent the range of variants constituting the respective haplotypes. CAD, coronary artery disease; MI, myocardial infarction; HTN, hypertension; OBS, obesity; lHDL, low high density lipoprotein. *P < 0.02 and **P < 0.01 by χ2 test.