|
SNP block
|
Haplotype
|
Trait
|
Pooled
|
Controls
|
Cases
|
χ2
|
P-value
|
|---|
|
1-8
|
GTGCCTCA
|
MI
|
0.025
|
0.022
|
0.029
|
4.13
|
0.042
|
| | |
HTN
|
0.025
|
0.021
|
0.029
|
6.40
|
0.011**
|
| | |
OBS
|
0.024
|
0.020
|
0.027
|
5.18
|
0.023*
|
|
1-7
|
GTGCCTC
|
CAD
|
0.025
|
0.021
|
0.030
|
7.17
|
0.007**
|
| | |
MI
|
0.025
|
0.023
|
0.030
|
4.41
|
0.036
|
| | |
HTN
|
0.025
|
0.021
|
0.030
|
7.17
|
0.007**
|
| | |
OBS
|
0.025
|
0.020
|
0.028
|
6.19
|
0.013**
|
|
1-6
|
GTGCCT
|
MI
|
0.025
|
0.023
|
0.030
|
4.40
|
0.036
|
| | |
HTN
|
0.025
|
0.021
|
0.030
|
7.19
|
0.007**
|
| | |
OBS
|
0.025
|
0.020
|
0.028
|
5.51
|
0.019**
|
|
1-5
|
GTGCC
|
MI
|
0.027
|
0.025
|
0.032
|
4.86
|
0.028
|
| | |
HTN
|
0.027
|
0.023
|
0.032
|
6.46
|
0.011**
|
| | |
OBS
|
0.026
|
0.022
|
0.029
|
4.22
|
0.040
|
|
1-4
|
GTGC
|
MI
|
0.028
|
0.025
|
0.033
|
5.06
|
0.025
|
| | |
HTN
|
0.028
|
0.023
|
0.032
|
6.60
|
0.010**
|
| | |
OBS
|
0.027
|
0.023
|
0.030
|
4.19
|
0.041
|
|
5-8
|
TCCA
|
OBS
|
0.025
|
0.029
|
0.022
|
4.95
|
0.026
|
| | |
lHDL
|
0.025
|
0.021
|
0.029
|
5.06
|
0.025
|
- The table lists some of the shared haplotypes constructed from the studied variants, rs224176 (1), rs6444174 (2), rs6773957 (3), rs1063537 (4), rs2082940 (5), rs4686804 (6), rs1063539 (7) and rs9842733 (8), arranged sequentially by their chromosomal positions. The most frequent 8-mer haplotype TTACCCCA (0.344) was employed as the baseline to determine the relative effects of these haplotypes. The pooled, control and case haplotype frequencies are proportions. SNP blocks represent the range of variants constituting the respective haplotypes. CAD, coronary artery disease; MI, myocardial infarction; HTN, hypertension; OBS, obesity; lHDL, low high density lipoprotein. *P < 0.02 and **P < 0.01 by χ2 test.
