Figure 2
From: A compound heterozygous mutation in HADHB gene causes an axonal Charcot-Marie-tooth disease
Histopathological findings of distal sural nerve biopsy in II-2. (A) Toluidine blue-stained semi-thin transverse section revealed absence of large MFs and remaining medium and small-sized MFs with frequently noted thin MFs (arrows) and occasionally noted axonal clusters (curved arrow). (B) Histogram showed unimodal distribution pattern of MF diameter. (C and D) Electron micrographs revealed MFs with pseudo-onion bulb formation and a thin MF compatible with remyelination. Original magnifications: A, x400; C, x3000; and D, x10000.