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Table 5 Association analysis of obesity with FTO haplotypes combinations

From: Influence of FTO variants on obesity, inflammation and cardiovascular disease risk biomarkers in Spanish children: a case–control multicentre study

Haplotypes

Frequency

  

All

Case

Control

OR (95% CI)

P

Block 1

     

ATTCGT

0.437

0.401

0.481

Reference

 

GGCCAA

0.425

0.483

0.355

1.26 (1.64 - 2.14)

5.11 × 10 -5

ATCGGT

0.080

0.073

0.087

0.99 (0.63 - 1.57 )

0.413

GGCCGT

0.025

0.019

0.031

0.65 (0.29 - 1.45)

0.133

Block 2

     

CATC

0.223

0.237

0.207

Reference

 

TGTC

0.297

0.258

0.345

0.65 (0.47-0.92)

0.002

TATC

0.212

0.225

0.196

1.02 (0.71-1.45)

0.231

TAGT

0.179

0.193

0.163

1.02 (0.70-1.51)

0.217

TAGC

0.053

0.063

0.041

1.29 (0.70 - 2.38)

0.143

  1. Block 1 involves SNPs: rs9928094, rs9930333, rs10852521, rs11075986, rs9935401, and rs9939609, Overall p value: 8.72 × 10-4. Block 2 involves SNPs: rs3826169, rs8061518, rs17818902, and rs7190053. Overall p value: 0.026.
  2. OR: odds ratio; CI: confidence interval.
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BMC Medical Genetics

ISSN: 1471-2350

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