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Table 5 Association analysis of obesity with FTO haplotypes combinations

From: Influence of FTO variants on obesity, inflammation and cardiovascular disease risk biomarkers in Spanish children: a case–control multicentre study

Haplotypes Frequency   
All Case Control OR (95% CI) P
Block 1      
ATTCGT 0.437 0.401 0.481 Reference  
GGCCAA 0.425 0.483 0.355 1.26 (1.64 - 2.14) 5.11 × 10 -5
ATCGGT 0.080 0.073 0.087 0.99 (0.63 - 1.57 ) 0.413
GGCCGT 0.025 0.019 0.031 0.65 (0.29 - 1.45) 0.133
Block 2      
CATC 0.223 0.237 0.207 Reference  
TGTC 0.297 0.258 0.345 0.65 (0.47-0.92) 0.002
TATC 0.212 0.225 0.196 1.02 (0.71-1.45) 0.231
TAGT 0.179 0.193 0.163 1.02 (0.70-1.51) 0.217
TAGC 0.053 0.063 0.041 1.29 (0.70 - 2.38) 0.143
  1. Block 1 involves SNPs: rs9928094, rs9930333, rs10852521, rs11075986, rs9935401, and rs9939609, Overall p value: 8.72 × 10-4. Block 2 involves SNPs: rs3826169, rs8061518, rs17818902, and rs7190053. Overall p value: 0.026.
  2. OR: odds ratio; CI: confidence interval.
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