Table 4 Association of rs8061518 with anthropometric, clinical, inflammation and CVD risk biomarkers in children
Biomarkers | AA | AG | GG | β (95% CI) | P | P a |
|---|---|---|---|---|---|---|
N | 254 | 215 | 54 | |||
Anthropometric factors | ||||||
Height (m) | 1.39 ± 0.01 | 1.40 ± 0.01 | 1.39 ± 0.02 | −0.001 (−0.01, 0.00) | 0.613 | 0.107 |
Weight (kg) | 46.8 ± 1.2 | 44.9 ± 1.3 | 42.6 ± 2.4 | −2.44 (−4.35, -0.54) | 0.012 | 0.130 |
BMI (kg/m2) | 23.70 ± 0.38 | 22.33 ± 0.42 | 21.48 ± 0.81 | −1.27 (−2.05, -0.50) | 0.001 | -- |
BMI z-score | 2.16 ± 0.14 | 1.61 ± 0.14 | 1.36 ± 0.30 | −0.45 (−0.72, -0.17) | 0.001 | -- |
Waist circumference (cm) | 74.74 ± 1.07 | 71.99 ± 1.18 | 71.10 ± 2.25 | −1.70 (−4.63, 1.22) | 0.254 | 0.534 |
Clinical and metabolic biomarkers | ||||||
Systolic BP (mm Hg) | 106 ± 1 | 103 ± 1 | 104 ± 2 | −1.74 (−3.69, 0.21) | 0.080 | 0.758 |
Diastolic BP (mm Hg) | 66 ± 1 | 64 ± 1 | 61 ± 1 | −2.23 (−3.80, -0.65) | 0.006 | 0.083 |
Glucose (mg/dl) | 85 ± 0 | 84 ± 0 | 85 ± 1 | −0.11 (−1.02, 0.80) | 0.816 | 0.836 |
Insulin (mU/l) | 9.52 ± 0.48 | 8.56 ± 0.48 | 8.17 ± 1.13 | −0.05 (−0.09, -0.02) | 0.003 | 0.153 |
HOMA-IR | 2.02 ± 0.10 | 1.80 ± 0.11 | 1.79 ± 0.30 | −0.05 (−0.09, -0.02) | 0.003 | 0.153 |
Triacylglycerols (mg/dl) | 68 ± 2 | 63 ± 2 | 66 ± 6 | −2.33 (−6.52, 1.86) | 0.276 | 0.995 |
ApoAI (mg/dl) | 141 ± 2 | 137 ± 2 | 145 ± 4 | 0.15 (−3.40, 3.71) | 0.932 | 0.330 |
Cholesterol (mg/dl) | 166 ± 2 | 168 ± 2 | 172 ± 4 | 0.01 (−0.004, 0.02) | 0.223 | 0.287 |
HDL-c (mg/dl) | 57 ± 1 | 56 ± 1 | 58 ± 2 | 0.07 (−1.87, 2.01) | 0.945 | 0.107 |
Adiponectin (mg/l) | 25.46 ± 0.77 | 23.92 ± 0.73 | 27.90 ± 1.81 | 0.38 (−1.15, 1.91) | 0.628 | 0.741 |
Resistin (μg/l) | 11.34 ± 0.40 | 10.30 ± 0.33 | 10.37 ± 0.72 | −0.68 (−1.42, 0.06) | 0.074 | 0.227 |
Leptin (μg/l) | 16.98 ± 1.02 | 12.57 ± 0.85 | 11.21 ± 1.70 | −3.55 (−5.43, -1.66) | <0.001 | 0.041 |
Inflammatory biomarkers | ||||||
C-reactive protein (mg/l) | 2.50 ± 0.26 | 2.26 ± 0.31 | 1.70 ± 0.30 | −0.34 (−0.89, 0.20) | 0.217 | 0.784 |
IL-6 (ng/l) | 5.62 ± 0.64 | 6.56 ± 0.90 | 4.71 ± 0.91 | 0.09 (−1.36, 1.53) | 0.905 | 0.705 |
IL-8 (ng/l) | 1.94 ± 0.14 | 1.98 ± 0.17 | 1.57 ± 0.19 | −0.10 (−0.39, 0.19) | 0.495 | 0.804 |
TNFα (ng/l) | 3.62 ± 0.14 | 3.51 ± 0.14 | 3.60 ± 0.27 | −0.05 (−0.32, 0.22) | 0.711 | 0.696 |
Cardiovascular disease risk biomarkers | ||||||
MMP-9 (μg/l) | 82.62 ± 3.42 | 86.21 ± 4.14 | 84.12 ±8.05 | 0.01 (−0.03, 0.04) | 0.764 | 0.754 |
MPO (μg/l) | 19.19 ± 1.68 | 16.65 ± 1.44 | 16.55 ± 4.26 | −1.63 (−4.94, 1.68) | 0.336 | 0.712 |
sE-Selectin (μg/l) | 28.19 ± 0.98 | 26.13 ± 1.08 | 26.61 ± 2.34 | −1.09 (−3.13, 0.95) | 0.296 | 0.924 |
sICAM-1 (mg/l) | 0.165 ± 0.004 | 0.168 ± 0.005 | 0.155 ± 0.007 | −0.002 (−0.01, 0.01) | 0.605 | 0.923 |
Active PAI-1 (μg/l) | 9.81 ± 0.62 | 8.45 ± 0.49 | 6.16 ± 0.63 | −1.71 (−2.80, -0.62) | 0.002 | 0.067 |
Total PAI-1 (μg/l) | 24.74 ± 1.11 | 22.56 ± 1.16 | 20.66 ± 1.85 | −0.04 (−0.08, 0.003) | 0.073 | 0.350 |