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Table 1 Anthropometric, clinical and biochemical parameters of the children

From: Influence of FTO variants on obesity, inflammation and cardiovascular disease risk biomarkers in Spanish children: a case–control multicentre study

  Normal-weight Obese P
n 242 292  
Anthropometric factors
Sex (M/F) 135/107 149/143 0.273
Age (y) 9.73 ± 0.2 9.43 ± 0.2 0.172
Weight (kg) 32.9 ± 0.7 55.9 ± 1.0 <0.001
Height (m) 1.37 ± 0.01 1.41 ± 0.01 0.001
BMI (kg/m2) 17.14 ± 0.13 27.56 ± 0.24 <0.001
BMI z-score −0.17 ± 0.04 3.49 ± 0.08 <0.001
Waist circumference (cm) 60.2 ± 0.5 84.0 ± 0.9 <0.001
Clinical and metabolic biomarkers
Systolic BP (mm Hg) 97 ± 1 111 ± 1 <0.001
Diastolic BP (mm Hg) 60 ± 1 69 ± 1 <0.001
Glucose (mg/dl) 84 ± 0 85 ± 1 0.772
Insulin (mU/l) 5.95 ± 0.23 11.46 ± 0.51 <0.001
HOMA-IR 1.26 ± 0.05 2.43 ± 0.12 <0.001
Triacylglycerols (mg/dl) 55 ± 1 75 ± 2 <0.001
ApoAI (mg/dl) 150 ± 2 132 ± 1 <0.001
ApoB (mg/dl) 67 ± 1 71 ± 1 0.008
Cholesterol (mg/dl) 171 ± 2 165 ± 2 0.012
HDL-c (mg/dl) 64 ± 1 51 ± 1 <0.001
LDL-c (mg/dl) 94 ± 2 97 ± 1 0.144
Adiponectin (mg/l) 28.28 ± 0.77 22.57 ± 0.66 <0.001
Resistin (μg/l) 9.65 ± 0.33 11.71 ± 0.34 <0.001
Leptin (μg/l) 4.30 ± 0.26 22.91 ± 0.86 <0.001
Inflammatory biomarkers
C-reactive protein (mg/l) 0.48 ± 0.07 1.99 ± 0.16 <0.001
Interleukin 6 (ng/l) 4.50 ± 0.53 6.95 ± 0.75 0.012
Interleukin 8 (ng/l) 1.57 ± 0.11 2.16 ± 0.15 0.003
TNF-α (ng/l) 3.06 ± 0.11 4.01 ± 0.13 <0.001
Cardiovascular disease risk biomarkers
MMP-9 (μg/l) 79.99 ± 3.15 88.42 ± 3.90 0.636
MPO (μg/l) 13.10 ± 1.16 21.51 ±1.70 <0.001
sE selectin (μg/l) 22.93 ± 0.76 31.26 ± 1.05 <0.001
sICAM-1 (mg/l) 0.153 ± 0.004 0.175 ± 0.005 <0.001
Active PAI-1 (μg/l) 5.16 ± 0.27 11.96 ± 0.57 <0.001
Total PAI-1 (μg/l) 18.95 ± 0.85 27.23 ± 1.01 <0.001
  1. M: male; F: female; BMI: body mass index; BP: blood pressure; HOMA-IR: homeostasis model assessment for insulin resistance; Apo: apolipoprotein; HDL-c: high-density lipoprotein cholesterol; LDL-c: low-density lipoprotein cholesterol; TNF-α: tumor necrosis factor alpha; MMP-9: metalloproteinase-9; MPO: myeloperoxidase; sICAM-1: soluble intracellular adhesion molecule-1, PAI-1: plasminogen activator inhibitor.
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