Vitamin D-responsive SGPP2 variants associated with lung cell expression and lung function

BMC Medical Genetics

Table 3 The association of SNPs in vitamin D-responsive genes (nominal P < 2.0 × 10 ^-02 ) with FEV ₁ (mL) for European-Americans in the Health, Aging and Body Composition study (sorted by gene)*

Gene	RS#	Chr	Coded allele	MAF (%)	β**	SE	Nominal P	Model
*DAPK1*	rs11141878	9	A	36	-103.98	36.3	4.26 × 10^-03	R
	rs4877361†	9	G	14	72.47	27.4	8.17 × 10^-03	D
	rs4878089	9	A	46	39.68	16.9	1.92 × 10^-02	A
*SGPP2*	rs4674656	2	A	25	-58.70	19.7	2.88 × 10^-03	A

†one redundant SNP not shown.
*Abbreviations: Chr, chromosome; MAF, minor allele frequency; β, regression coefficient; SE, standard error; A = additive genetic model, D = dominant model, R = recessive model.
**Beta-coefficient estimates the association of allele with FEV₁, based on genetic model shown and adjusted for age, height, smoking, gender, study site, and ancestry principal components.

ISSN: 1471-2350