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Table 1 Fold change in expression and P-value of 13 genes reaching nominal P-value Threshold (p < 0.05) in expression study

From: Vitamin D-responsive SGPP2 variants associated with lung cell expression and lung function

Gene

Chromosome

Fold change*

P-value

R2§

KCNS3

2

-1.62

0.00084

28%

FSTL1

3

-1.55

0.00163

40%

DAPK1

9

-2.06

0.00381

17%

RSAD2

2

1.41

0.01103

16%

CST6

11

1.79

0.01516

20%

KAL1

X

-1.38

0.01840

28%

SLITRK6

13

-1.52

0.02482

25%

TMEM40

3

1.55

0.02518

23%

EMB

5

1.52

0.03099

23%

PTGER2

14

1.36

0.03574

9%

DTX4

11

-1.34

0.03812

15%

KLF4

9

1.66

0.03901

9%

SGPP2

2

1.69

0.04491

24%

  1. *Fold change in high versus low tertile serum 25-hydroxyvitamin D.
  2. §R-squared calculated in linear regression, considering the full range of serum 25-hydroxyvitamin D, thus equals the proportion of variance in expression accounted for serum 25(OH)D.