Skip to main content

Table 3 Frequency of NF2-gene mutations in our patients and other series from the literature reporting >10 sporadic meningiomas

From: Association between mutation of the NF2gene and monosomy 22 in menopausal women with sporadic meningiomas

Reference No of mutated cases/total cases (%) Exons involved
Ruttledge, et al., 1994 [27]** 24/170 (14%) 2-7-8-9-10-11-12
LeKanne Deprez, et al., 1994 [26]** 19/48 (40%) 1-2-3-4-5-6-11-12
Merel, et al., 1995 [25]** 15/57 (26%) 1-2-3-4-5-6-7-8-9-12-13
Wellenreuther, et al., 1995 [24] 41/70 (59%) 1-2-3-4-5-6-7-8-10-11-12-13
Ng, et al., 1995 [23] 7/26 (27%) 4-5-6-7-10
Papi, et al., 1995 [22]** 9/61 (15%) 2-5-7-8-11
Harada, et al., 1996 [21] 8/23 (35%) 1-2-5-8-11-12
Ruttledge, et al., 1996 [20] 67/111 (60%) 1-2-3-4-6-7-8-10-11-12-13-14-15-17
De Vitis, et al., 1996 [29] 37/125 (30%) 2-3-4-5-6-7-8-11-12-13
Stangl, et al., 1997 [18] 10/12 (83%) 3-5-6-7-8-11-12
Leone, et al., 1999 [17]** 11/81 (14%) 2-7-11
Ueki, et al., 1999 [16] 10/50 (20%) 4-5-7-10-12-13
Evans, et al., 2001 [14] 4/27 (15%) 3-4-8-13
Joachim, et al., 2001 [13]* 26/61 (43%) 1-2-3-4-5-6-7-8-10-11-12-13
Szijan, et al., 2003 [11] 5/14 (35%) 2-3-8-12-13
Lomas, et al., 2005 [10]** 21/88 (24%) 1-2-3-4-7-11-12-13
Hartmann, et al., 2006 [9]# 21/80 (20%) 1-2-3-4-5-6-7-8-9-11-12-13-14-15
Kim, et al., 2006 [8]** 20/42 (48%) 1-2-4-5-7-10-11-12
Hansson, et al., 2007 [7]** 39/100 (39%) 1-2-3-4-6-7-8-9-10-12-13-14
Goutagny, et al., 2010 [6]& 14/18 (78%) 2-5-6-7-8-10-11-12-13
Tabernero et al. (2013) 6/20 (30%) 2-3-5-9-12
Total 414/1284 (32%) 1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-17
  1. *several radiation-induced meningiomas were included in this series; #infrequent subtypes of meningiomas were analyzed in this series; &meningioma cases showing progression were analyzed in this series.
  2. **not all exones of the NF2 gene were investigated in this series.