Table 1 Clinical, histopathological and genetic characteristics of meningioma patients grouped according to the presence vs absence of NF2 gene mutations (n = 20)
Patient features | NF2-mutated meningiomas | Non-mutated meningiomas | p-value | |
|---|---|---|---|---|
(n = 6) | (n = 14) | |||
Age (median in years) | 73 (56–82) | 53 (26–80) | 0.03 | |
Gender (Male/Female) | 0/6 | 3/11 | 0.32 | |
(0%/100%) | (21%/79%) | |||
Skull base | 1 (17%) | 7 (50%) | ||
Tumor localization | Convexity | 1 (17%) | 2 (14%) | 0.37 |
Tentorium | 4 (66%) | 4 (29%) | ||
Spinal | 0 (0%) | 1 (7%) | ||
Histological subtype | Meningothelial | 2 (33%) | 8 (57%) | |
Transitional | 3 (50%) | 4 (29%) | NS | |
Fibroblastic | 1 (17%) | 2 (14%) | ||
Chromosome 22 status by iFISH | Diploid | 0 (0%) | 9 (64%) | 0.005 |
del(22q) | 0 (0%) | 3 (22%) | ||
Monosomy 22 | 6 (100%) | 2 (14%) | ||
Cytogenetic subgroups | Diploid | 0 (0%) | 7 (50%) | 0.03 |
Isolated monosomy 22 | 4 (67%) | 2 (14%) | ||
Complex-karyotype: with monosomy 22 | 2 (33%) | 1 (7%) | ||
with del(22q) | 0 (0%) | 2 (14%) | ||
Complex-karyotype w/o −22/del(22q) | 0 (0%) | 2 (14%) | ||