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Table 1 Clinical, histopathological and genetic characteristics of meningioma patients grouped according to the presence vs absence of NF2 gene mutations (n = 20)

From: Association between mutation of the NF2gene and monosomy 22 in menopausal women with sporadic meningiomas

Patient features NF2-mutated meningiomas Non-mutated meningiomas p-value
(n = 6) (n = 14)
Age (median in years) 73 (56–82) 53 (26–80) 0.03
Gender (Male/Female) 0/6 3/11 0.32
(0%/100%) (21%/79%)
  Skull base 1 (17%) 7 (50%)  
Tumor localization Convexity 1 (17%) 2 (14%) 0.37
Tentorium 4 (66%) 4 (29%)  
Spinal 0 (0%) 1 (7%)  
Histological subtype Meningothelial 2 (33%) 8 (57%)  
Transitional 3 (50%) 4 (29%) NS
Fibroblastic 1 (17%) 2 (14%)  
Chromosome 22 status by iFISH Diploid 0 (0%) 9 (64%) 0.005
del(22q) 0 (0%) 3 (22%)
Monosomy 22 6 (100%) 2 (14%)
Cytogenetic subgroups Diploid 0 (0%) 7 (50%) 0.03
Isolated monosomy 22 4 (67%) 2 (14%)
Complex-karyotype:  with monosomy 22 2 (33%) 1 (7%)
          with del(22q) 0 (0%) 2 (14%)
Complex-karyotype   w/o −22/del(22q) 0 (0%) 2 (14%)