Table 2 Anthropometric and quantitative metabolic characteristics of 5,645 middle-aged Danish Inter99 participants stratified according to the AGPAT6 rs17600159 genotype

N (men/women)

4835(2373/2462)

641(317/324)

19(10/9)

Age (years)

45.9 ± 7.9

45.8 ± 7.5

46.7 ± 7.9

Waist (cm)

85.9 ± 12.9

85.9 ± 12.9

90.7 ± 12.9

0.56

BMI (kg/m²)

26.0 ± 4.4

25.9 ± 4.4

27.8 ± 5.1

0.82

Serum Triglycerides (mmol/l)

1.3 ± 1.4

1.3 ± 1.1

1.2 ± 0.5

0.34

Serum Total cholesterol (mmol/l)

5.5 ± 1.1

5.5 ± 1.0

5.2 ± 1.0

0.92

Serum HDL cholesterol (mmol/l)

1.4 ± 0.4

1.4 ± 0.4

1.4 ± 0.3

0.61

Plasma glucose (mmol/l)

  Fasting

5.45 ± 0.51

5.47 ± 0.51

5.43 ± 0.55

0.36

  120 min

5.93 ± 1.52

6.06 ± 1.64

6.76 ± 1.57

0.025

Serum insulin (pmol/l)

  Fasting

41 ± 26

40.3 ± 24.4

41.8 ± 22.7

0.85

  120 min

206 ± 198

212 ± 184

374 ± 410

0.013

Insulin secretion indices

Insulinogenic index

29.8 ± 19.7

30.2 ± 18.8

35.0 ± 30.4

0.32

BIGTT-AIR

1860 ± 1096

1859 ± 1017

2372 ± 2177

0.59

Insulin sensitivity indices

HOMA-IR (pmol x mmol/l)

9.98 ± 6.84

9.95 ± 6.42

10.09 ± 5.44

0.80

BIGTT-S_I

9.49 ± 3.94

9.26 ± 3.94

7.97 ± 4.42

0.075

Stumvoll S_I

0.10 ± 0.02

0.10 ± 0.02

0.09 ± 0.03

0.34

Matsuda S_I

9.19 ± 5.69

8.94 ± 5.69

7.80 ± 4.56

0.15