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Table 6 Relationship between the Bantu haplotype and HU treatment on SCA patients

From: Genetic and biochemical markers of hydroxyurea therapeutic response in sickle cell anemia

 

Sample groups

P values*

Group I

Group II

Group III

Gruop IV

n = 11

n = 08

n = 04

n = 05

Hb F ( % )

6.42 ± 4.45a

13.55 ± 7.66b

5.45 ± 5.42a

6.74 ± 3.46a

0.0388

TBARS (ng/mL)

2023.18 ± 490.74a

1099.99 ± 455.70b

1327.00 ± 463.9b

1335.57 ± 241.94b

0.0009

TEAC (mM)

1.99 ± 0.16

2.06 ± 0.15

1.88 ± 0.27

2.09 ± 0.10

0.2296

GST (U/mL)

1.68 ± 0.90

1.44 ± 0.55

1.64 ± 0.53

1.61 ± 0.34

0.8974

CAT (U/mL)

1756.72 ± 385.98

2156.25 ± 540.32

1515.85 ± 759.98

1728.17 ± 446.54

0.1758

GSH (μM)

0.81 ± 0.44

0.79 ± 0.45

0.52 ± 0.24

0.55 ± 0.41

0.4987

  1. *Different letters indicate statistical differences (ANOVA followed by Fisher’s post hoc test).
  2. Group I: Bantu (−HU), Group II: Bantu (+ HU), Group III: any haplotype except Bantu (−HU), Group IV: any haplotype except Bantu (+ HU).
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BMC Medical Genetics

ISSN: 1471-2350

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