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Table 6 Relationship between the Bantu haplotype and HU treatment on SCA patients

From: Genetic and biochemical markers of hydroxyurea therapeutic response in sickle cell anemia

  Sample groups P values*
Group I Group II Group III Gruop IV
n = 11 n = 08 n = 04 n = 05
Hb F ( % ) 6.42 ± 4.45a 13.55 ± 7.66b 5.45 ± 5.42a 6.74 ± 3.46a 0.0388
TBARS (ng/mL) 2023.18 ± 490.74a 1099.99 ± 455.70b 1327.00 ± 463.9b 1335.57 ± 241.94b 0.0009
TEAC (mM) 1.99 ± 0.16 2.06 ± 0.15 1.88 ± 0.27 2.09 ± 0.10 0.2296
GST (U/mL) 1.68 ± 0.90 1.44 ± 0.55 1.64 ± 0.53 1.61 ± 0.34 0.8974
CAT (U/mL) 1756.72 ± 385.98 2156.25 ± 540.32 1515.85 ± 759.98 1728.17 ± 446.54 0.1758
GSH (μM) 0.81 ± 0.44 0.79 ± 0.45 0.52 ± 0.24 0.55 ± 0.41 0.4987
  1. *Different letters indicate statistical differences (ANOVA followed by Fisher’s post hoc test).
  2. Group I: Bantu (−HU), Group II: Bantu (+ HU), Group III: any haplotype except Bantu (−HU), Group IV: any haplotype except Bantu (+ HU).