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Table 3 Two-point LOD score on chromosome 2q33-34 from the linkage analysis using all 22 family members

From: Combinational analysis of linkage and exome sequencing identifies the causative mutation in a Chinese family with congenital cataract

Marker

Mb

LOD Score atθ=

Z max

θ max

  

0

0.1

0.2

0.3

0.4

  

D2S364

183

-3.09

1.07

1.16

0.94

0.53

1.16

0.2

D2S117*,#

195.6

-4.25

0.39

0.37

0.23

0.09

0.39

0.1

D2S2318*

198.7

0.71

0.76

0.64

0.46

0.24

0.76

0.1

D2S309*

201.9

-3.96

1.23

1.08

0.77

0.39

1.23

0.1

D2S2237*

205.6

3.53

2.94

2.28

1.54

0.73

3.53

0.0

D2S325*,#

208.2

2.15

1.98

1.61

1.13

0.59

2.15

0.0

D2S2178*

209.8

-3.4

1.67

1.39

0.95

0.46

1.67

0.1

D2S1385*

210.4

-3.55

0.94

0.85

0.6

0.3

0.94

0.1

D2S2382#

217

-5.06

0.44

0.58

0.43

0.14

0.58

0.2

D2S2250

219.7

-9.82

-1.04

-0.26

0.01

0.06

0.06

0.4

D2S126#

221

-3.12

0.59

0.76

0.64

0.37

0.76

0.2

D2S206#

233.7

-5.77

-1.38

-0.71

-0.35

-0.14

-0.14

0.4

  1. *Markers used for haplotyping.
  2. #Markers used for initial gene scan to exclude the known loci.