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Figure 4 | BMC Medical Genetics

Figure 4

From: Rare recessive loss-of-function methionyl-tRNA synthetase mutations presenting as a multi-organ phenotype

Figure 4

Location of the mutated residues I523 and F370 in human MARS. A: Homology modeling of human MARS (purple) with E. coli MARS (pink, PDB 1PFU) in complex with methionine phosphinate (grey, with elements colored in red (oxygen), orange (phosphorus), yellow (sulfur) and blue (nitrogen)). B: Close-up of the methionine binding pocket. Residues that interact with methionine are represented by sticks (pink). Residue I523 of human MARS (purple sticks) is located close to the methionine binding pocket, but does not directly interact with methionine. C: Residue F370 (purple sticks) is located in an alpha-helix close to residue I523.

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BMC Medical Genetics

ISSN: 1471-2350

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