From: Effects of vitamin D receptor polymorphisms on urolithiasis risk: a meta-analysis
 |  | Sample size | No. of studies | Test of association |  | Heterogeneity | |||||
---|---|---|---|---|---|---|---|---|---|---|---|
Polymorphisms | Study | Case | Control | OR (95% CI) | Z | P Value | Model | χ 2 | PValue | I 2(%) | |
ApaI | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
AA vs. aa | Overall | 846 | 1048 | 11 | 1.47 (1.11-1.94) | 2.66 | 0.008 | R | 13.03 | 0.220 | 23.0 |
aA vs. aa | Overall | 1059 | 1368 | 11 | 1.30 (1.06-1.60) | 2.54 | 0.010 | R | 10.98 | 0.360 | 9.0 |
AA vs. aA | Overall | 1263 | 1290 | 11 | 1.04 (0.76-1.43) | 0.25 | 0.810 | R | 26.31 | 0.003 | 62.0 |
AA + aA vs. aa | Overall | 1584 | 1853 | 11 | 1.34 (1.11-1.60) | 3.12 | 0.002 | R | 7.49 | 0.680 | 0.0 |
AA + aA vs. aa | Asian | 1200 | 1468 | 7 | 1.43 (1.16-1.75) | 4.57 | <0.001 | R | 4.57 | 0.600 | 0.0 |
AA + aA vs. aa | Caucasian | 384 | 385 | 4 | 1.08 (0.74-1.57) | 0.40 | 0.690 | R | 1.32 | 0.730 | 0.0 |
AA + aA vs. aa | Hypercalciuria | 295 | 262 | 4 | 1.24 (0.86-1.81) | 1.15 | 0.250 | R | 3.10 | 0.380 | 3.0 |
AA + aA vs. aa | Adult | 1328 | 1148 | 8 | 1.30 (1.04-1.62) | 2.33 | 0.020 | R | 3.99 | 0.780 | 0.0 |
AA + aA vs. aa | HWE | 1328 | 1148 | 8 | 1.30 (1.04-1.62) | 2.33 | 0.020 | R | 3.99 | 0.780 | 0.0 |
AA + aA vs. aa | High quality | 1319 | 1662 | 8 | 1.34 (1.09-1.66) | 2.75 | 0.006 | R | 7.41 | 0.390 | 6.0 |
BsmI | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
bb vs. BB | Overall | 841 | 855 | 8 | 1.79 (0.98-3.26) | 1.89 | 0.060 | R | 18.93 | 0.008 | 63.0 |
bB vs. BB | Overall | 611 | 609 | 8 | 1.85 (1.03-3.32) | 2.05 | 0.040 | R | 21.94 | 0.003 | 68.0 |
bb vs. bB | Overall | 966 | 856 | 8 | 0.96 (0.77-1.20) | 0.33 | 0.740 | R | 5.01 | 0.660 | 0.0 |
bb + bB vs. BB | Overall | 1210 | 1160 | 8 | 1.81 (1.03-3.17) | 2.07 | 0.040 | R | 23.82 | 0.001 | 71.0 |
bb + bB vs. BB | Asian | 738 | 640 | 3 | 1.21 (0.67-2.32) | 0.69 | 0.490 | R | 3.10 | 0.210 | 36.0 |
bb + bB vs. BB | Caucasian | 472 | 520 | 5 | 2.43 (1.02-5.80) | 2.00 | 0.050 | R | 19.52 | <0.001 | 80.0 |
bb + bB vs. BB | Hypercalciuria | 123 | 340 | 3 | 2.43 (1.36-4.35) | 2.99 | 0.003 | R | 1.99 | 0.370 | 0.0 |
bb + bB vs. BB | Adult | 1146 | 1070 | 7 | 1.80 (0.96-3.38) | 1.83 | 0.070 | R | 23.65 | <0.001 | 75.0 |
bb + bB vs. BB | HWE | 909 | 820 | 5 | 1.36 (0.87-2.13) | 1.35 | 0.180 | R | 4.90 | 0.300 | 18.0 |
bb + bB vs. BB | High quality | 794 | 709 | 3 | 1.15 (0.75-1.72) | 0.66 | 0.510 | R | 1.01 | 0.600 | 0.0 |
FokI | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
ff vs. FF | Overall | 1144 | 1243 | 14 | 1.59 (1.08-2.35) | 2.34 | 0.020 | R | 47.26 | <0.001 | 72.0 |
fF vs. FF | Overall | 1647 | 1809 | 14 | 1.38 (0.96-2.00) | 1.72 | 0.090 | R | 64.13 | <0.001 | 80.0 |
ff vs. fF | Overall | 1741 | 1804 | 14 | 1.04 (0.74-1.45) | 0.22 | 0.830 | R | 56.68 | <0.001 | 77.0 |
ff + fF vs. FF | Overall | 2266 | 2418 | 14 | 1.48 (1.03-2.12) | 2.12 | 0.030 | R | 68.26 | <0.001 | 81.0 |
ff + fF vs. FF | Asian | 2005 | 2188 | 12 | 1.32 (0.94-1.86) | 1.62 | 0.110 | R | 44.62 | <0.001 | 75.0 |
ff + fF vs. FF | Hypercalciuria | 324 | 560 | 5 | 1.15 (0.81-1.63) | 0.79 | 0.430 | R | 1.42 | 0.840 | 0.0 |
ff + fF vs. FF | Adult | 2024 | 1743 | 11 | 1.71 (1.14-2.56) | 2.61 | 0.009 | R | 59.01 | <0.001 | 83.0 |
ff + fF vs. FF | HWE | 1390 | 1125 | 7 | 1.05 (0.83-1.33) | 0.39 | 0.700 | R | 8.54 | 0.200 | 30.0 |
ff + fF vs. FF | High quality | 1513 | 1348 | 7 | 1.34 (0.83-2.16) | 1.19 | 0.230 | R | 53.59 | <0.001 | 85.0 |
TaqI | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
tt vs. TT | Overall | 1144 | 1478 | 13 | 1.24 (0.92-1.68) | 1.40 | 0.160 | R | 12.19 | 0.430 | 2.0 |
tT vs. TT | Overall | 1558 | 1786 | 13 | 1.33 (1.04-1.70) | 2.28 | 0.020 | R | 21.41 | 0.040 | 44.0 |
tt vs. Tt | Overall | 806 | 624 | 13 | 0.92 (0.61-1.38) | 0.40 | 0.690 | R | 21.56 | 0.040 | 44.0 |
tt + tT vs. TT | Overall | 1744 | 1944 | 13 | 1.30 (1.08-1.55) | 2.79 | 0.005 | R | 13.54 | 0.330 | 11.0 |
tt + tT vs. TT | Asian | 1110 | 1386 | 6 | 1.39 (1.11-1.73) | 2.87 | 0.004 | R | 4.32 | 0.500 | 0.0 |
tt + tT vs. TT | Caucasian | 644 | 558 | 7 | 1.21 (0.84-1.72) | 1.02 | 0.310 | R | 10.06 | 0.120 | 40.0 |
tt + tT vs. TT | Hypercalciuria | 176 | 183 | 5 | 1.56 (1.06-2.31) | 2.24 | 0.030 | R | 2.47 | 0.650 | 0.0 |
tt + tT vs. TT | Adult | 1481 | 1244 | 9 | 1.34 (1.05-1.71) | 2.35 | 0.020 | R | 12.71 | 0.120 | 37.0 |
tt + tT vs. TT | HWE | 1098 | 964 | 7 | 1.36 (1.07-1.77) | 2.51 | 0.010 | R | 7.44 | 0.280 | 19.0 |
tt + tT vs. TT | High quality | 1392 | 1676 | 8 | 1.27 (1.05-1.54) | 2.43 | 0.010 | R | 9.23 | 0.240 | 24.0 |
ApaI-TaqI haplotype |  |  |  |  |  |  |  |  |  |  |  |
At vs. aT | Overall | 830 | 1207 | 4 | 1.35 (1.09-1.68) | 2.71 | 0.007 | R | 2.91 | 0.410 | 0.0 |
At vs. aT | Asian | 644 | 961 | 3 | 1.53 (1.17-2.00) | 3.14 | 0.002 | R | 0.35 | 0.840 | 0.0 |
At vs. aT | Adult | 752 | 806 | 3 | 1.36 (1.03-1.80) | 2.16 | 0.030 | R | 2.90 | 0.230 | 31.0 |