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Table 2 Association of 12 SNPs with rickets in cases and controls

From: Relationship between polymorphisms in vitamin D metabolism-related genes and the risk of rickets in Han Chinese children

Gene SNP MAF p for HWET A/a Allele-specific (unadjusted) Allele-specific (adjusted)
      p value OR (95% CI) p valueb OR (95% CI)
GC rs4588 0.31 0.30 Ca/A 0.003 0.587 (0.412-0.836) 0.003 0.583 (0.409-0.833)
rs7041 0.26 0.29 T/Ga 0.252 1.216 (0.867-1.705) 0.167 1.272 (0.901-1.791)
rs222020 0.34 0.67 T/Ca 0.009 1.526 (1.117-2.085) 0.009 1.517 (1.108-2.078)
rs2282679 0.32 0.22 Aa/C 0.010 0.636 (0.449-0.900) 0.010 0.631 (0.444-0.895)
rs2298849 0.32 0.98 T/Ca 0.001 1.709 (1.250-2.338) 0.001 1.722 (1.256-2.362)
CYP2R1 rs10741657 0.43 0.25 Ga/A 0.019 1.467 (1.070-2.011) 0.016 1.477 (1.075-2.030)
rs10766197 0.45 0.36 Ga/A 0.374 0.855 (0.619-1.179) 0.416 0.874 (0.632-1.209)
rs12794714 0.43 0.36 G/Aa 0.089 1.322 (0.968-1.804) 0.075 1.330 (0.971-1.820)
rs1562902 0.47 0.46 Ta/C 0.120 1.279 (0.940-1.740) 0.115 1.284 (0.941-1.751)
rs2060793 0.27 0.42 Ga/A 0.023 0.689 (0.502-0.944) 0.019 0.684 (0.498-0.940)
DHCR7/NADSYN1 rs3829251 0.28 0.59 G/Aa 0.297 1.204 (0.863-1.680) 0.342 1.176 (0.841-1.645)
  rs12785878 0.49 0.13 Ta/G 1.000 0.993 (0.733-1.345) 0.879 0.977 (0.719-1.326)
  1. A/a major allele/minor allele.
  2. arisk allele.
  3. badjusted for sex and BMI.
  4. MAF, minor allele frequency in the study population.
  5. HWE, P values for Hardy–Weinberg Equilibrium test in the study population.
  6. Significant P values are indicated by a triangle ( P<0.05).