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Table 2 Association of 12 SNPs with rickets in cases and controls

From: Relationship between polymorphisms in vitamin D metabolism-related genes and the risk of rickets in Han Chinese children

Gene

SNP

MAF

p for HWET

A/a

Allele-specific (unadjusted)

Allele-specific (adjusted)

     

p value

OR (95% CI)

p valueb

OR (95% CI)

GC

rs4588

0.31

0.30

Ca/A

0.003

0.587 (0.412-0.836)

0.003

0.583 (0.409-0.833)

rs7041

0.26

0.29

T/Ga

0.252

1.216 (0.867-1.705)

0.167

1.272 (0.901-1.791)

rs222020

0.34

0.67

T/Ca

0.009

1.526 (1.117-2.085)

0.009

1.517 (1.108-2.078)

rs2282679

0.32

0.22

Aa/C

0.010

0.636 (0.449-0.900)

0.010

0.631 (0.444-0.895)

rs2298849

0.32

0.98

T/Ca

0.001

1.709 (1.250-2.338)

0.001

1.722 (1.256-2.362)

CYP2R1

rs10741657

0.43

0.25

Ga/A

0.019

1.467 (1.070-2.011)

0.016

1.477 (1.075-2.030)

rs10766197

0.45

0.36

Ga/A

0.374

0.855 (0.619-1.179)

0.416

0.874 (0.632-1.209)

rs12794714

0.43

0.36

G/Aa

0.089

1.322 (0.968-1.804)

0.075

1.330 (0.971-1.820)

rs1562902

0.47

0.46

Ta/C

0.120

1.279 (0.940-1.740)

0.115

1.284 (0.941-1.751)

rs2060793

0.27

0.42

Ga/A

0.023

0.689 (0.502-0.944)

0.019

0.684 (0.498-0.940)

DHCR7/NADSYN1

rs3829251

0.28

0.59

G/Aa

0.297

1.204 (0.863-1.680)

0.342

1.176 (0.841-1.645)

 

rs12785878

0.49

0.13

Ta/G

1.000

0.993 (0.733-1.345)

0.879

0.977 (0.719-1.326)

  1. A/a major allele/minor allele.
  2. arisk allele.
  3. badjusted for sex and BMI.
  4. MAF, minor allele frequency in the study population.
  5. HWE, P values for Hardy–Weinberg Equilibrium test in the study population.
  6. Significant P values are indicated by a triangle ( P<0.05).