|
SNP
|
Gene
|
Severity
|
Z
|
P
|
SPT
|
Z
|
P
|
|---|
| | |
Fam
|
Score
|
value
|
Fam
|
Score
|
value
|
|---|
|
rs2305480 C/T
|
GSDMB
|
272
|
-3.791
|
1.5×10
-4
|
220
|
-3.164
|
1.6×10-3
|
|
rs11078927 C/T
|
GSDMB
|
277
|
-3.701
|
2.2 ×10
-4
|
227
|
-3.133
|
1.7×10-3
|
|
rs1342326 T/G
|
IL33
|
180
|
+1.378
|
0.168
|
144
|
+2.585
|
9.7×10-3
|
|
rs3939286 G/A
|
IL33
|
204
|
+0.347
|
0.729
|
164
|
+2.146
|
0.032
|
|
rs3771166 C/T
|
IL18R1
|
269
|
-2.021
|
0.043
|
219
|
-1.683
|
0.092
|
|
rs1420101 G/A
|
IL1RL1
|
263
|
+1.577
|
0.115
|
218
|
+0.449
|
0.653
|
|
rs744910 A/G
|
SMAD3
|
268
|
+0.386
|
0.699
|
215
|
+0.157
|
0.875
|
|
rs2284033 A/G
|
IL2RB
|
268
|
+1.233
|
0.218
|
216
|
+1.265
|
0.206
|
|
rs1588265 A/G
|
PDE4D
|
235
|
-0.712
|
0.477
|
195
|
-0.360
|
0.719
|
|
rs2786098 C/A
|
CRB1
|
202
|
-1.021
|
0.307
|
158
|
-1.886
|
0.059
|
|
rs2244012 A/G
|
RAD50
|
188
|
+0.941
|
0.347
|
159
|
+1.242
|
0.214
|
- FBAT was used to test for association using the additive model [17]. SNP single nucleotide polymorphism, MAF minor allele frequency, Fam number of families in analysis (≥10 families). Severity = BTS classification (1–5) [18], SPT = positive skin prick test to one or more allergen. Bonferroni correction, P < 9.1×10-4 considered significant (bold).
