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Table 4 Association of key GWAS SNPs with asthma severity defined by BTS steps and atopy

From: Defining the contribution of SNPs identified in asthma GWAS to clinical variables in asthmatic children

SNP Gene Severity Z P SPT Z P
   Fam Score value Fam Score value
rs2305480 C/T GSDMB 272 -3.791 1.5×10 -4 220 -3.164 1.6×10-3
rs11078927 C/T GSDMB 277 -3.701 2.2 ×10 -4 227 -3.133 1.7×10-3
rs1342326 T/G IL33 180 +1.378 0.168 144 +2.585 9.7×10-3
rs3939286 G/A IL33 204 +0.347 0.729 164 +2.146 0.032
rs3771166 C/T IL18R1 269 -2.021 0.043 219 -1.683 0.092
rs1420101 G/A IL1RL1 263 +1.577 0.115 218 +0.449 0.653
rs744910 A/G SMAD3 268 +0.386 0.699 215 +0.157 0.875
rs2284033 A/G IL2RB 268 +1.233 0.218 216 +1.265 0.206
rs1588265 A/G PDE4D 235 -0.712 0.477 195 -0.360 0.719
rs2786098 C/A CRB1 202 -1.021 0.307 158 -1.886 0.059
rs2244012 A/G RAD50 188 +0.941 0.347 159 +1.242 0.214
  1. FBAT was used to test for association using the additive model [17]. SNP single nucleotide polymorphism, MAF minor allele frequency, Fam number of families in analysis (≥10 families). Severity = BTS classification (1–5) [18], SPT = positive skin prick test to one or more allergen. Bonferroni correction, P < 9.1×10-4 considered significant (bold).