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Table 3 Association of key GWAS SNPs with asthma diagnosis, percent predicted FEV 1 and bronchial hyperresponsiveness to methacholine

From: Defining the contribution of SNPs identified in asthma GWAS to clinical variables in asthmatic children

SNP Gene Asthma Z P FEV 1 Z P BHR Z P
   Fam Score value Fam Score value Fam Score value
rs2305480 C/T GSDMB 265 -3.323 8.9×10 -4 274 -3.247 1.1×10-3 240 -3.345 8.2×10 -4
rs11078927 C/T GSDMB 272 -3.305 9.5×10-4 278 -3.330 8.7×10 -4 244 -3.238 1.2×10-3
rs1342326 T/G IL33 176 +1.114 0.265 180 +1.266 0.205 156 +1.412 0.158
rs3939286 G/A IL33 198 +0.412 0.680 204 +0.544 0.586 176 +0.693 0.489
rs3771166 C/T IL18R1 263 -1.475 0.140 270 -1.637 0.102 228 -1.416 0.157
rs1420101 G/A IL1RL1 261 +0.899 0.369 264 +0.658 0.511 223 +0.737 0.461
rs744910 A/G SMAD3 264 +0.116 0.907 271 +0.823 0.411 234 -0.166 0.868
rs2284033 A/G IL2RB 262 +0.825 0.409 267 +0.416 0.677 233 +0.778 0.436
rs1588265 A/G PDE4D 233 -0.380 0.703 239 -0.056 0.956 205 -0.506 0.613
rs2786098 C/A CRB1 202 -1.702 0.089 204 -1.324 0.185 178 -2.377 0.017
rs2244012 A/G RAD50 187 +0.953 0.340 189 +0.659 0.510 164 +1.075 0.282
  1. FBAT was used to test for association using the additive model [17]. SNP single nucleotide polymorphism, MAF minor allele frequency, Fam number of families in analysis (≥10 families). Asthma = Doctor diagnosed asthma, FEV1 = FEV1 percent predicted, BHR = PC20 (methacholine 4 mg/ml) only available in Southampton Families, Bonferroni correction, P < 9.1×10-4 considered significant (bold).