Defining the contribution of SNPs identified in asthma GWAS to clinical variables in asthmatic children

BMC Medical Genetics

Table 3 Association of key GWAS SNPs with asthma diagnosis, percent predicted FEV ₁ and bronchial hyperresponsiveness to methacholine

SNP	Gene	Asthma	Z	P	FEV ₁	Z	P	BHR	Z	P
		Fam	Score	value	Fam	Score	value	Fam	Score	value
rs2305480 C/T	GSDMB	265	-3.323	8.9×10 ^-4	274	-3.247	1.1×10^-3	240	-3.345	8.2×10 ^-4
rs11078927 C/T	GSDMB	272	-3.305	9.5×10^-4	278	-3.330	8.7×10 ^-4	244	-3.238	1.2×10^-3
rs1342326 T/G	IL33	176	+1.114	0.265	180	+1.266	0.205	156	+1.412	0.158
rs3939286 G/A	IL33	198	+0.412	0.680	204	+0.544	0.586	176	+0.693	0.489
rs3771166 C/T	IL18R1	263	-1.475	0.140	270	-1.637	0.102	228	-1.416	0.157
rs1420101 G/A	IL1RL1	261	+0.899	0.369	264	+0.658	0.511	223	+0.737	0.461
rs744910 A/G	SMAD3	264	+0.116	0.907	271	+0.823	0.411	234	-0.166	0.868
rs2284033 A/G	IL2RB	262	+0.825	0.409	267	+0.416	0.677	233	+0.778	0.436
rs1588265 A/G	PDE4D	233	-0.380	0.703	239	-0.056	0.956	205	-0.506	0.613
rs2786098 C/A	CRB1	202	-1.702	0.089	204	-1.324	0.185	178	-2.377	0.017
rs2244012 A/G	RAD50	187	+0.953	0.340	189	+0.659	0.510	164	+1.075	0.282

FBAT was used to test for association using the additive model [17]. SNP single nucleotide polymorphism, MAF minor allele frequency, Fam number of families in analysis (≥10 families). Asthma = Doctor diagnosed asthma, FEV₁ = FEV₁ percent predicted, BHR = PC₂₀ (methacholine 4 mg/ml) only available in Southampton Families, Bonferroni correction, P < 9.1×10^-4 considered significant (bold).

ISSN: 1471-2350