From: Reduced genetic influence on childhood obesity in small for gestational age children
Gene | SNP | Tested allele | AGA | SGA | Adjusted for SGA status | Interaction with SGA status (ref = AGA) | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 |  |  | Estimate (95% CI) | p value | q value | Estimate (95% CI) | p value | q value | Estimate (95% CI) | p value | q value | Estimate (95% CI) | p value | q value |
ADIPOR2 | rs2286385 | T | 0.165 (0.065-0.265) | 0.0012 | 0.0073* | 0.035 (−0.093-0.162) | 0.5950 | 0.3941 | 0.110 (0.031-0.190) | 0.0063 | 0.0207* | −0.131 (−0.294-0.031) | 0.1134 | 0.1176 |
BDNF | rs6265 | G | 0.123 (0.002-0.244) | 0.0470 | 0.0650 | 0.203 (0.040-0.365) | 0.0146 | 0.0303* | 0.159 (0.059-0.260) | 0.0018 | 0.0095* | 0.079 (−0.123-0.282) | 0.4429 | 0.3117 |
CTNNBL1 | rs16986921 | T | 0.231 (−0.023-0.484) | 0.0742 | 0.0848 | 0.259 (−0.058-0.576) | 0.1089 | 0.1160 | 0.245 (0.042-0.449) | 0.0180 | 0.0346* | 0.030 (−0.377-0.436) | 0.8867 | 0.4992 |
CTNNBL1 | rs6013029 | T | 0.295 (0.044-0.547) | 0.0214 | 0.0368* | 0.310 (−0.015-0.634) | 0.0611 | 0.0764 | 0.303 (0.099-0.507) | 0.0036 | 0.0149* | 0.016 (−0.396-0.428) | 0.9401 | 0.5099 |
CTNNBL1 | rs6020395 | C | 0.185 (−0.043-0.413) | 0.1108 | 0.1164 | 0.458 (0.126-0.791) | 0.0069 | 0.0212* | 0.303 (0.109-0.498) | 0.0022 | 0.0108* | 0.274 (−0.130-0.677) | 0.1836 | 0.1608 |
CTNNBL1 | rs6020712 | A | 0.309 (0.050-0.568) | 0.0193 | 0.0357* | 0.233 (−0.074-0.539) | 0.1372 | 0.1352 | 0.270 (0.068-0.472) | 0.0087 | 0.0227 | −0.077 (−0.479-0.325) | 0.7085 | 0.4432 |
CTNNBL1 | rs6020846 | G | 0.219 (−0.008-0.446) | 0.0591 | 0.0751 | 0.287 (−0.019-0.594) | 0.0663 | 0.0794 | 0.251 (0.064-0.438) | 0.0085 | 0.0227 | 0.068 (−0.315-0.452) | 0.7265 | 0.4509 |
CTNNBL1 | rs6096781 | C | 0.209 (−0.025-0.444) | 0.0805 | 0.0894 | 0.313 (−0.103-0.729) | 0.1408 | 0.1370 | 0.249 (0.034-0.464) | 0.0232 | 0.0389 | 0.103 (−0.376-0.582) | 0.6742 | 0.4320 |
CTNNBL1 | rs6125962 | C | 0.204 (−0.017-0.424) | 0.0700 | 0.0811 | 0.276 (−0.029-0.582) | 0.0763 | 0.0859 | 0.237 (0.054-0.421) | 0.0113 | 0.0241* | 0.072 (−0.306-0.450) | 0.7076 | 0.4432 |
FAIM2 | rs7138803 | A | 0.117 (0.015-0.219) | 0.0249 | 0.0407* | −0.015 (−0.150-0.119) | 0.8220 | 0.4799 | 0.059 (−0.023-0.141) | 0.1609 | 0.1492 | −0.132 (−0.301-0.037) | 0.1250 | 0.1279 |
FTO | rs6499640 | A | 0.051 (−0.043-0.145) | 0.2905 | 0.2290 | 0.153 (0.046-0.260) | 0.0050 | 0.0188* | 0.097 (0.027-0.168) | 0.0070 | 0.0212* | 0.103 (−0.039-0.246) | 0.1562 | 0.1466 |
FTO | rs8050136 | A | 0.143 (0.042-0.243) | 0.0055 | 0.0195* | 0.137 (0.011-0.263) | 0.0335 | 0.0489* | 0.141 (0.062-0.219) | 4.8e-04 | 0.0042* | −0.005 (−0.166-0.158) | 0.9569 | 0.5130 |
FTO | rs9939609 | A | 0.148 (0.048-0.248) | 0.0038 | 0.0150* | 0.154 (0.028-0.279) | 0.0164 | 0.0331* | 0.300 (0.117-0.482) | 1.8e-04 | 0.0021* | 0.007 (−0.154-0.169) | 0.9290 | 0.5099 |
HMGA2 | rs1042725 | C | 0.104 (0.010-0.198) | 0.0304 | 0.0470* | 0.062 (−0.058-0.183) | 0.3090 | 0.2411 | 0.087 (0.013-0.161) | 0.0215 | 0.0368* | −0.041 (−0.194-0.112) | 0.6015 | 0.3951 |
KCTD15 | rs11084753 | A | 0.067 (−0.036-0.169) | 0.2019 | 0.1749 | 0.155 (0.037-0.274) | 0.0104 | 0.0234* | 0.103 (0.026-0.181) | 0.0090 | 0.0227* | 0.088 (−0.069-0.244) | 0.2732 | 0.2199 |
MAF | rs1424233 | A | 0.052(−0.042 -0.146) | 0.2758 | 0.2199 | −0.130 (−0.263-0.003) | 0.0552 | 0.0725 | −0.024 (−0.103-0.054) | 0.5446 | 0.3669 | −0.183 (−0.347- -0.020) | 0.0280 | 0.0441* |
MC4R | rs12970134 | A | 0.290 (0.191-0.389) | 1.0e-08 | 8.0e-07* | −0.060 (−0.204-0.085) | 0.4194 | 0.3061 | 0.153 (0.069-0.236) | 3.3e-04 | 0.0033* | −0.350 (−0.525- -0.174) | 9.6e-05 | 0.0015* |
MC4R | rs17700633 | A | 0.120 (0.015-0.225) | 0.0253 | 0.0407* | −0.047 (−0.164-0.070) | 0.4299 | 0.3080 | 0.044 (−0.035-0.123) | 0.2762 | 0.2199 | −0.167 (−0.325- -0.010) | 0.0374 | 0.0536 |
MC4R | rs17782313 | C | 0.204 (0.105-0.303) | 5.6e-05 | 0.0011* | −0.006 (−0.147-0.136) | 0.9398 | 0.5099 | 0.122 (0.041-0.204) | 0.0032 | 0.0140* | −0.210 (−0.383- -0.037) | 0.0176 | 0.0346* |
MC4R | rs4450508 | A | 0.189 (0.091-0.286) | 1.5e-04 | 0.0019* | 0.021 (−0.115-0.158) | 0.7610 | 0.4622 | 0.122 (0.041-0.202) | 0.0029 | 0.0134* | −0.168 (−0.336-0.0) | 0.0496 | 0.0674 |
MC4R | rs502933 | A | 0.168 (0.070-0.266) | 7.5e-04 | 0.0053* | 0.009 (−0.129-0.148) | 0.8944 | 0.4999 | 0.107 (0.027-0.188) | 0.0092 | 0.0227* | −0.159 (−0.329-0.011) | 0.0665 | 0.0794 |
MTMR9 | rs2293855 | A | 0.162 (0.063-0.261) | 0.0013 | 0.0073* | −0.039 (−0.156-0.079) | 0.5208 | 0.3538 | 0.079 (0.003-0.156) | 0.0427 | 0.0601 | −0.199 (−0.353- -0.045) | 0.0113 | 0.0241* |
NEGR1 | rs2568958 | A | −0.053 (−0.139-0.033) | 0.2280 | 0.1953 | 0.135 (0.021-0.250) | 0.0203 | 0.0364* | 0.021 (0.048-0.090) | 0.5526 | 0.3691 | 0.189 (0.046-0.332) | 0.0097 | 0.0227* |
NEGR1 | rs2815752 | T | −0.059 (−0.146-0.028) | 0.1810 | 0.1603 | 0.133 (0.021-0.245) | 0.0195 | 0.0357* | 0.017 (0.052-0.085) | 0.6359 | 0.4108 | 0.193 (0.052-0.334) | 0.0075 | 0.0214* |
PTER | rs10508503 | C | 0.307 (0.166-0.448) | 2.1e-05 | 8.2e-04* | −0.009 (−0.258-0.240) | 0.9446 | 0.5099 | 0.190 (0.055-0.324) | 0.0057 | 0.0195* | −0.314 (−0.602- -0.026) | 0.0327 | 0.0489* |
SEC16B | rs10913469 | C | 0.215 (0.089-0.341) | 8.4e-04 | 0.0053* | 0.199 (0.048-0.350) | 0.0098 | 0.0227* | 0.207 (0.110-0.305) | 3.1e-05 | 8.2e-04* | −0.016 (−0.213-0.181) | 0.8759 | 0.4966 |
SH2B1 | rs7498665 | G | −0.100 (−0.191- -0.008) | 0.0334 | 0.0489* | 0.163 (0.043-0.283) | 0.0076 | 0.0214* | 0.006 (−0.067-0.080) | 0.8664 | 0.4966 | 0. 263 (0.112-0.414) | 6.3e-04 | 0.0050* |