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Table 2 Analysis of association between SNPs and repeated measures of BMI z-score

From: Reduced genetic influence on childhood obesity in small for gestational age children

Gene

SNP

Tested allele

AGA

SGA

Adjusted for SGA status

Interaction with SGA status (ref = AGA)

   

Estimate (95% CI)

p value

q value

Estimate (95% CI)

p value

q value

Estimate (95% CI)

p value

q value

Estimate (95% CI)

p value

q value

ADIPOR2

rs2286385

T

0.165 (0.065-0.265)

0.0012

0.0073*

0.035 (−0.093-0.162)

0.5950

0.3941

0.110 (0.031-0.190)

0.0063

0.0207*

−0.131 (−0.294-0.031)

0.1134

0.1176

BDNF

rs6265

G

0.123 (0.002-0.244)

0.0470

0.0650

0.203 (0.040-0.365)

0.0146

0.0303*

0.159 (0.059-0.260)

0.0018

0.0095*

0.079 (−0.123-0.282)

0.4429

0.3117

CTNNBL1

rs16986921

T

0.231 (−0.023-0.484)

0.0742

0.0848

0.259 (−0.058-0.576)

0.1089

0.1160

0.245 (0.042-0.449)

0.0180

0.0346*

0.030 (−0.377-0.436)

0.8867

0.4992

CTNNBL1

rs6013029

T

0.295 (0.044-0.547)

0.0214

0.0368*

0.310 (−0.015-0.634)

0.0611

0.0764

0.303 (0.099-0.507)

0.0036

0.0149*

0.016 (−0.396-0.428)

0.9401

0.5099

CTNNBL1

rs6020395

C

0.185 (−0.043-0.413)

0.1108

0.1164

0.458 (0.126-0.791)

0.0069

0.0212*

0.303 (0.109-0.498)

0.0022

0.0108*

0.274 (−0.130-0.677)

0.1836

0.1608

CTNNBL1

rs6020712

A

0.309 (0.050-0.568)

0.0193

0.0357*

0.233 (−0.074-0.539)

0.1372

0.1352

0.270 (0.068-0.472)

0.0087

0.0227

−0.077 (−0.479-0.325)

0.7085

0.4432

CTNNBL1

rs6020846

G

0.219 (−0.008-0.446)

0.0591

0.0751

0.287 (−0.019-0.594)

0.0663

0.0794

0.251 (0.064-0.438)

0.0085

0.0227

0.068 (−0.315-0.452)

0.7265

0.4509

CTNNBL1

rs6096781

C

0.209 (−0.025-0.444)

0.0805

0.0894

0.313 (−0.103-0.729)

0.1408

0.1370

0.249 (0.034-0.464)

0.0232

0.0389

0.103 (−0.376-0.582)

0.6742

0.4320

CTNNBL1

rs6125962

C

0.204 (−0.017-0.424)

0.0700

0.0811

0.276 (−0.029-0.582)

0.0763

0.0859

0.237 (0.054-0.421)

0.0113

0.0241*

0.072 (−0.306-0.450)

0.7076

0.4432

FAIM2

rs7138803

A

0.117 (0.015-0.219)

0.0249

0.0407*

−0.015 (−0.150-0.119)

0.8220

0.4799

0.059 (−0.023-0.141)

0.1609

0.1492

−0.132 (−0.301-0.037)

0.1250

0.1279

FTO

rs6499640

A

0.051 (−0.043-0.145)

0.2905

0.2290

0.153 (0.046-0.260)

0.0050

0.0188*

0.097 (0.027-0.168)

0.0070

0.0212*

0.103 (−0.039-0.246)

0.1562

0.1466

FTO

rs8050136

A

0.143 (0.042-0.243)

0.0055

0.0195*

0.137 (0.011-0.263)

0.0335

0.0489*

0.141 (0.062-0.219)

4.8e-04

0.0042*

−0.005 (−0.166-0.158)

0.9569

0.5130

FTO

rs9939609

A

0.148 (0.048-0.248)

0.0038

0.0150*

0.154 (0.028-0.279)

0.0164

0.0331*

0.300 (0.117-0.482)

1.8e-04

0.0021*

0.007 (−0.154-0.169)

0.9290

0.5099

HMGA2

rs1042725

C

0.104 (0.010-0.198)

0.0304

0.0470*

0.062 (−0.058-0.183)

0.3090

0.2411

0.087 (0.013-0.161)

0.0215

0.0368*

−0.041 (−0.194-0.112)

0.6015

0.3951

KCTD15

rs11084753

A

0.067 (−0.036-0.169)

0.2019

0.1749

0.155 (0.037-0.274)

0.0104

0.0234*

0.103 (0.026-0.181)

0.0090

0.0227*

0.088 (−0.069-0.244)

0.2732

0.2199

MAF

rs1424233

A

0.052(−0.042 -0.146)

0.2758

0.2199

−0.130 (−0.263-0.003)

0.0552

0.0725

−0.024 (−0.103-0.054)

0.5446

0.3669

−0.183 (−0.347- -0.020)

0.0280

0.0441*

MC4R

rs12970134

A

0.290 (0.191-0.389)

1.0e-08

8.0e-07*

−0.060 (−0.204-0.085)

0.4194

0.3061

0.153 (0.069-0.236)

3.3e-04

0.0033*

−0.350 (−0.525- -0.174)

9.6e-05

0.0015*

MC4R

rs17700633

A

0.120 (0.015-0.225)

0.0253

0.0407*

−0.047 (−0.164-0.070)

0.4299

0.3080

0.044 (−0.035-0.123)

0.2762

0.2199

−0.167 (−0.325- -0.010)

0.0374

0.0536

MC4R

rs17782313

C

0.204 (0.105-0.303)

5.6e-05

0.0011*

−0.006 (−0.147-0.136)

0.9398

0.5099

0.122 (0.041-0.204)

0.0032

0.0140*

−0.210 (−0.383- -0.037)

0.0176

0.0346*

MC4R

rs4450508

A

0.189 (0.091-0.286)

1.5e-04

0.0019*

0.021 (−0.115-0.158)

0.7610

0.4622

0.122 (0.041-0.202)

0.0029

0.0134*

−0.168 (−0.336-0.0)

0.0496

0.0674

MC4R

rs502933

A

0.168 (0.070-0.266)

7.5e-04

0.0053*

0.009 (−0.129-0.148)

0.8944

0.4999

0.107 (0.027-0.188)

0.0092

0.0227*

−0.159 (−0.329-0.011)

0.0665

0.0794

MTMR9

rs2293855

A

0.162 (0.063-0.261)

0.0013

0.0073*

−0.039 (−0.156-0.079)

0.5208

0.3538

0.079 (0.003-0.156)

0.0427

0.0601

−0.199 (−0.353- -0.045)

0.0113

0.0241*

NEGR1

rs2568958

A

−0.053 (−0.139-0.033)

0.2280

0.1953

0.135 (0.021-0.250)

0.0203

0.0364*

0.021 (0.048-0.090)

0.5526

0.3691

0.189 (0.046-0.332)

0.0097

0.0227*

NEGR1

rs2815752

T

−0.059 (−0.146-0.028)

0.1810

0.1603

0.133 (0.021-0.245)

0.0195

0.0357*

0.017 (0.052-0.085)

0.6359

0.4108

0.193 (0.052-0.334)

0.0075

0.0214*

PTER

rs10508503

C

0.307 (0.166-0.448)

2.1e-05

8.2e-04*

−0.009 (−0.258-0.240)

0.9446

0.5099

0.190 (0.055-0.324)

0.0057

0.0195*

−0.314 (−0.602- -0.026)

0.0327

0.0489*

SEC16B

rs10913469

C

0.215 (0.089-0.341)

8.4e-04

0.0053*

0.199 (0.048-0.350)

0.0098

0.0227*

0.207 (0.110-0.305)

3.1e-05

8.2e-04*

−0.016 (−0.213-0.181)

0.8759

0.4966

SH2B1

rs7498665

G

−0.100 (−0.191- -0.008)

0.0334

0.0489*

0.163 (0.043-0.283)

0.0076

0.0214*

0.006 (−0.067-0.080)

0.8664

0.4966

0. 263 (0.112-0.414)

6.3e-04

0.0050*

  1. * Remain significant after applying multiple testing correction using false discovery rate.