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Table 7 De novo variants

From: Whole-exome sequencing of a pedigree segregating asthma

         Mother    Father   Child 1   Child 2   Child 3   Child 4
Function Gene Exonic function Chr2 Position Gen3 Reads4 Gen3 Reads4 Gen3 Reads4 Gen3 Reads4 Gen3 Reads4 Gen3 Reads4
exonic MEF2A nonsyn1 15 100252908 0/0 155,0 0/0 187,0 0/1 73,65 0/0 223,0 0/0 76,0 0/0 196,3
exonic DST nonsyn1 6 56485113 0/0 221,0 0/0 333,1 0/0 248,0 0/0 326,0 0/0 145,0 0/1 168,122
  1. 1Nonsynonymous.
  2. 2Chromosome.
  3. 3Genotype (0/0 = homozygous reference, 0/1 = heterozygous for the de novo variant, 1/1 = homozygous de novo).
  4. 4Number of reads covering the variant site with the first number being the number of reads containing the reference allele and the second the number of reads containing the de novo variant allele.