Figure 2

PDLIM5 mRNA expression level in control subjects and patients at 0, 4, and 8 weeks after olanzapine treatment. The mean PDLIM5 mRNA expression level was significantly lower in naïve patients than in control subjects (naïve patients: 0.31±0.245; controls: 1.42±1.42; Wilcoxon rank sum test: *p=0.002). After 4 weeks of treatment, no significant changes were detected in PDLIM5 mRNA expression when compared with the mean mRNA level in treatment-naïve patients (after 4 weeks of treatment: 0.36±0.195; Wilcoxon rank sum test: p=0.826). The PDLIM5 mRNA expression level after 8 weeks was 0.36±0.244, with no statistical difference when compared with the mRNA level after 4 weeks of treatment (Wilcoxon rank sum test: p=0.937). The mean PDLIM5 mRNA expression level in controls and patients before and after treatment is indicated by horizontal lines.