Table 3 Association of children’s fasting glucose, HbA1c levels, and genetic risk scores, with IQ at age 8
Exposure | N (unadjusted/adjusted) | Mean difference in IQ per unit change in exposure (95% CI) | p-value | Adjusted by child’s age and sex | p-value |
|---|---|---|---|---|---|
fasting glucose (mmol/l) | 784/784 | −1.94 (−4.71, 0.82) | 0.17 | −2.22 (−5.01, 0.56) | 0.12 |
HbA1c (%) | 1198/1198 | 0.43 (−2.53, 3.40) | 0.78 | 0.65 (−2.29, 3.59) | 0.67 |
Genetic risk score | N (unadjusted/adjusted) | Mean difference in IQ per weighted allele (95% CI) | p-value | Adjusted by PCs | p-value |
FGGRS | 3904/3457 | −0.09 (−0.26, 0.08) | 0.29 | −0.11 (−0.30, 0.07) | 0.22 |
T2DGRS | 3468/3053 | 0.01 (−0.15, 0.18) | 0.87 | 0.06 (−0.12, 0.24) | 0.52 |