Model

No heterogeneity

Heterogeneity in variance components by gender



Hazard ratio

Variance components

Hazard ratio

Variance components



Sex

σ^{2}
_{g}

σ^{2}
_{f}

Sex

σ^{2}
_{g,m}

σ^{2}
_{g,f}

σ^{2}
_{f}


Polygenic

0.43***

0.58
 
0.43***

0.21

0.40
 
 
(0.330.91)
  
(0.010.54)

(0.110.78)
 
Polygenic and shared family

0.43***

0.37

0.17

0.42***

0.03

0.28

0.25

 
(0.140.70)

(0.050.39)
 
(0.000.35)

(0.010.65)

(0.120.48)

 ***p ≤ 0.001; σ^{2}
_{g}: polygenic variance estimate; σ^{2}
_{g,m}: polygenic variance estimate for males; σ^{2}
_{g,f}: polygenic variance estimate for females; σ^{2}
_{f}: variance estimate for shared family effect.