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Table 2 Exact replication of previously reported GWAS associations 1 in a cohort of African Americans

From: Transferability and Fine Mapping of genome-wide associated loci for lipids in African Americans

SNP

Chr

Position

Minor Allele(Freq HUFS, Freq CEU)

Nearby Gene

Trait

HUFS

Previous Report

Beta (SE)

P-value

Beta (SE)

P-value

rs10401969

19

19268718

G (0.17, 0.10)

CILP2/SF4

TG

−8.3 (2.8)

0.006

−7.8 (0.8)

1.6 x 10-29

rs11869286

17

35067382

G (0.26, 0.68)

STARD3

HDL

2.1 (0.9)

0.02

−0.5 (0.08)2

2.8 x 10-14

rs12678919

8

19888502

G (0.11, 0.12)

LPL

TG

−9.0 (4.4)

0.01

−13.6 (0.6)

1.5 x 10-115

rs2081687

8

59551119

T (0.22, 0.33)

CYP7A1

LDL

5.2 (2.5)

0.04

0.95 (0.2)

3.9 x 10-9

rs2131925

1

62798530

T (0.37, 0.68)

ANGPTL3

TC

4.5 (2.3)

0.04

−2.6 (0.2)2

4.9 x 10-41

rs4420638

19

50114786

C (0.21, 0.18)

APOE

HDL

−2.3 (0.9)

0.02

−1.1 (0.1)

4.4 x 10-21

rs629301

1

109619829

G (0.36, 0.30)

SORT1

LDL

−5.4 (1.9)

0.005

−5.7 (0.2)

9.7 x 10-171

  1. 1Teslovich et al., Nature, 2010; 2The minor allele for HUFS is the major allele in previous report, thus the direction of effect should be reversed for comparison.