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Table 3 Results for dysmethylated promoter regions in primary tumors

From: Quantitative global and gene-specific promoter methylation in relation to biological properties of neuroblastomas

Case

Primary tumor

High-risk

Follow

BLU

Casp8 A1

CASP8 A2

DCR2

CDH1

RASSF1A

RASSF2

Total

CIMP

Z-score

LINE-1

no.

type

stage

MYCN

therapy

up

>10%

>10%

>50%

>30%

>10%

>30%

>10%

no.

 

all genes

%

1

NB

4S

-

-

NED

-

CASP8 A1

+ CASP8 A2

-

-

RASSF1A

-

2

-

- 0.30

64.8

2

NB

1

-

-

NED

-

CASP8 A1

+ CASP8 A2

-

-

RASSF1A

-

2

-

0.23

66.3

3

NB

3

-

-

NED

-

CASP8 A1

-

-

-

RASSF1A

-

2

-

- 0.04

58.0

4

NB

1

-

-

NED

-

-

-

DCR2

-

-

-

1

-

0.07

65.8

5

NB

4

yes

yes

DOD

-

-

-

-

-

-

-

-

-

- 0.11

68.2

6

NB

2A

-

-

NED

-

CASP8 A1

-

-

-

RASSF1A

-

2

-

- 0.33

55.7

7

NB

4

yes

yes

DOD

-

CASP8 A1

-

-

-

-

-

1

-

0.26

70.0

8

NB

2

-

-

NED

-

-

-

-

-

RASSF1A

-

1

-

- 0.65

58.2

9

NB

4

yes

yes

DOD

-

CASP8 A1

+ CASP8 A2

-

-

-

-

1

-

- 0.06

69.8

10

NB

4S

-

-

NED

-

-

-

-

-

-

-

-

-

- 0.37

62.9

11

NB

4

yes

yes

NED

-

CASP8 A1

+ CASP8 A2

-

-

-

-

1

-

- 0.06

66.4

12

NB

4

yes

yes

DOD

BLU

-

-

-

-

RASSF1A

-

2

-

0.57

62.4

13

Gang

-

-

-

NED

-

-

-

-

-

-

-

-

-

- 0.55

68.9

14

NB

3

yes

yes

NED

-

-

-

DCR2

-

RASSF1A

RASSF2

3

CIMP

1.19

57.0

15

Gang

-

-

-

NED

-

-

-

-

-

-

-

-

-

- 0.58

72.6

16

NB

4

yes

yes

NED

-

-

-

-

-

-

-

-

-

- 0.52

67.2

17

NB

2

-

-

NED

-

-

-

-

-

RASSF1A

-

1

-

- 0.14

57.1

18

NB

4

-

-

NED

-

CASP8 A1

-

DCR2

-

RASSF1A

-

3

CIMP

0.24

69.9

19

NB

3

-

-

NED

-

CASP8 A1

-

DCR2

-

RASSF1A

-

3

CIMP

0.55

59.7

20

NB

2

-

-

AWD

-

CASP8 A1

-

DCR2

CDH1

RASSF1A

-

4

CIMP

1.87

60.2

21

NB

4

yes

yes

NED

-

CASP8 A1

+ CASP8 A2

-

-

-

-

1

-

- 0.30

66.8

22

NB

2

-

-

NED

-

CASP8 A1

-

-

-

RASSF1A

-

2

-

0.21

55.6

23

NB

3

yes

yes

NED

BLU

-

CASP8 A2

-

-

-

-

2

-

- 0.32

65.9

24

NB

3

-

-

NED

-

CASP8 A1

+ CASP8 A2

-

-

RASSF1A

-

2

-

0.01

53.9

25

Gang

-

-

-

NED

-

-

-

-

-

-

-

-

-

. 0.62

65.9

26

NB

3

-

-

NED

-

CASP8 A1

+ CASP8 A2

-

-

-

-

2

-

- 0.25

59.7

27

NB

4

yes

yes

DOD

BLU

CASP8 A1

-

-

-

RASSF1A

-

3

CIMP

1.57

65.9

28

NB

4S

-

-

NED

-

CASP8 A1

-

-

-

RASSF1A

-

2

-

0.11

58.7

29

NB

3

-

-

DOC

-

CASP8 A1

+ CASP8 A2

-

-

RASSF1A

-

2

-

0.14

55.0

30

NB

1

-

-

DOC

-

-

-

-

-

RASSF1A

-

1

-

- 0.57

61.7

31

NB

1

-

-

NED

-

-

-

-

-

-

-

-

-

- 0.43

74.8

32

NB

2

-

-

DOD

-

CASP8 A1

-

-

-

RASSF1A

-

2

-

0.10

64.4

33

NB

1

-

-

NED

-

-

-

-

-

RASSF1A

-

1

-

- 0.28

67.7

34

NB

4

-

-

NED

-

-

-

-

-

-

-

-

-

- 0.29

71.5

35

NB

1

-

-

NED

BLU

CASP8 A1

-

-

-

RASSF1A

-

3

CIMP

- 0.20

67.9

36

NB

1

-

-

NED

-

CASP8 A1

-

-

-

RASSF1A

-

2

-

- 0.17

66.7

37

NB

3

yes

yes

NED

-

-

-

-

-

RASSF1A

-

1

-

0.48

66.0

38

NB

3

-

-

NED

-

CASP8 A1

-

-

-

RASSF1A

-

2

-

- 0.10

67.7

  1. NB = neuroblastoma; AWD 0 Alive with disease; DOD = Dead of disease, NED = No evidence of disease; DOC = Dead of surgical complications.
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BMC Medical Genetics

ISSN: 1471-2350

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