Single nucleotide polymorphisms in thymic stromal lymphopoietin gene are not associated with allergic rhinitis susceptibility in Chinese subjects

Table 4 Associations between common haplotypes near TSLP gene and AR risk

Block	AR subjects		Control subjects		P^a	P_sim ^b	Hap. Score^c	Logistic regression		Global score test^f
Block	No.	Frequency	No.	Frequency	P^a	P_sim ^b	Hap. Score^c	OR (95% CI)	P^d	Global score test^f
Block1: rs12654933-rs11466741-rs13156086
CCA	382	52.10%	339	52.30%	0.9211	0.6622	0.44067	1.00 (referent)		Global-stat = 0.49867, df = 4, p-val = 0.97363, P_sim ^b = 0.97596
CTC	180.3	24.60%	165.1	25.50%	0.6940	0.5274	−0.63567	0.933 (0.716-1.217)	0.610
ACA	109	14.90%	91.5	14.10%	0.7014	0.80357	0.25053	1.029 (0.743-1.426)	0.863
CTA	56.5	7.70%	48.4	7.50%	0.8739	0.83692	−0.20715	1.002 (0.604-1.664)	0.993
Others	5.1	0.70%	3.9	0.60%	NA^e	NA^e	NA^e	NA^e	NA^e
Block2: rs6886755-rs252706
GG	430.8	58.50%	383.1	58.90%	0.8761	0.70783	−0.37559	1.00 (referent)		Global-stat = 0.71243, df = 2, p-val = 0.70032, P_sim ^b = 0.70097
GA	252.1	34.30%	219.2	33.70%	0.8355	0.4783	0.70725	1.073 (0.845-1.362)	0.563
TG	53.1	7.20%	47.7	7.30%	0.9336	0.55034	−0.60092	0.913 (0.592-1.408)	0.681

AR = Allergic rhinitis.
a. P value for difference in haplotype frequency between AR and control subjects.
b. Generated by permutation test with 100,000 times simulation.
c. A positive (or negative) score for a particular haplotype would have suggested that the haplotype was associated with increased (or decreased) risk of allergic rhinitis.
d. P values from unconditional logistic regression analyses, adjusted for age and gender.
e. NA, not available because of the rarity of genotype.
f. df, degrees of freedom.

ISSN: 1471-2350