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Table 3 Genotype frequencies of 9 tag SNPs among AR and control subjects, and their associations with AR risk

From: Single nucleotide polymorphisms in thymic stromal lymphopoietin gene are not associated with allergic rhinitis susceptibility in Chinese subjects

SNP ID

Genotype

AR subjects

Control subjects

P (2 df)a

Logistic regression

No.

Frequency

No.

Frequency

OR (95%CI)

Pb

rs12653736

GG

290

79.89%

255

78.95%

0.852

1.00 (referent)

 
 

GT

66

18.18%

63

19.50%

 

0.999 (0.667-1.496)

0.996

 

TT

7

1.93%

5

1.55%

 

1.073 (0.322-3.572)

0.909

rs1837253

TT

98

26.85%

90

28.66%

0.828

1.00 (referent)

 
 

TC

186

50.96%

159

50.64%

 

1.043 (0.719-1.514)

0.823

 

CC

81

22.19%

65

20.70%

 

1.078 (0.686-1.696)

0.744

rs12654933

CC

269

73.30%

237

73.37%

0.659

1.00 (referent)

 
 

CA

86

23.43%

79

24.46%

 

1.012 (0.701-1.463)

0.948

 

AA

12

3.27%

7

2.17%

 

1.151 (0.429-3.092)

0.780

rs10455025

AA

333

90.74%

292

90.40%

0.622

1.00 (referent)

 
 

AC

33

8.99%

31

9.60%

 

0.867 (0.503-1.492)

0.605

 

CC

1

0.27%

0

0.00%

 

NAc

NAc

rs11466741

CC

134

46.69%

112

46.67%

0.879

1.00 (referent)

 
 

CT

121

42.16%

98

40.83%

 

0.993 (0.675-1.461)

0.972

 

TT

32

11.15%

30

12.50%

 

0.816 (0.454-1.469)

0.498

rs13156086

AA

198

58.24%

169

56.52%

0.909

1.00 (referent)

 
 

AC

120

35.29%

110

36.79%

 

0.903 (0.639-1.277)

0.564

 

CC

22

6.47%

20

6.69%

 

0.826 (0.423-1.613)

0.576

rs6886755

GG

317

86.38%

276

85.71%

0.624

1.00 (referent)

 
 

GT

47

12.81%

45

13.98%

 

0.793 (0.501-1.256)

0.323

 

TT

3

0.82%

1

0.31%

 

2.535 (0.255-25.235)

0.428

rs252706

GG

163

44.54%

149

46.27%

0.831

1.00 (referent)

 
 

GA

155

42.35%

129

40.06%

 

1.174 (0.837-1.646)

0.353

 

AA

48

13.11%

44

13.66%

 

1.120 (0.684-1.832)

0.653

rs2416259

TT

139

38.08%

126

42.14%

0.335

1.00 (referent)

 
 

TC

176

48.22%

127

42.47%

 

1.361 (0.960-1.928)

0.083

 

CC

50

13.70%

46

15.38%

 

1.122 (0.689-1.828)

0.644

  1. AR = Allergic rhinitis.
  2. a. Global P values [2 degrees of freedom (df)]: genotype frequencies in AR and control subjects were compared using a χ2 test with 2 df.
  3. b. P values from unconditional logistic regression analyses, adjusted for age and gender.
  4. c. NA, not available because of the rarity of genotype.